Validation of a new analytical model for peritoneal transport model using rabbit in vivo experimental data

Computer simulation techniques may be useful for considering an appropriate treatment schedule for peritoneal dialysis by using a mathematical model. The authors derived a new approximated analytical solution for Pyle-Popovich's peritoneal dialysis model that is known to simulate peritoneal transport quantitatively. In the present study, the validity of the new model was demonstrated by comparing it with another approximated analytical solution derived by other researchers using rabbit in vivo experimental data taken under normal continuous ambulatory peritoneal dialysis (CAPD) mode. The new model showed much better agreement with the experimental data no matter how the plasma concentration changed during the course of the experiment. The new analytical solution can simulate the change of metabolite concentration in the plasma using clinical data at an arbitrary treatment time.