Validation of pretransplantation assessment of mortality risk score in the outcome of hematopoietic SCT in non-Caucasians

Y. Mori, T. Teshima, K. Kamezaki, K. Kato, K. Takenaka, H. Iwasaki, T. Miyamoto, K. Nagafuji, T. Eto, K. Akashi

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7 Citations (Scopus)

Abstract

The Pretransplantation Assessment of Mortality (PAM) score is a risk score for mortality after allogeneic hematopoietic SCT (HSCT). Ethnicity is a genetically determined factor that correlated with immune-mediated outcomes of allogeneic HSCT. We evaluated the predictive value of the PAM score for transplant outcome in 276 Japanese populations in which transplant-related complications occur less frequently than Caucasians. The PAM score effectively risk-stratified these patients for survival; overall survival (OS) at 2 years was 100%, 80.2%, 49.4%, and 13.9% in the categories 1, 2, 3, and 4, respectively, showing a clear distinction of OS by categories (P0.001). In addition, the PAM score is useful for the prediction of transplant outcomes both in patients with standard-risk underlying diseases and those with high-risk diseases. The PAM score developed in Caucasian populations is thus useful in non-Caucasian populations.

Original languageEnglish
Pages (from-to)1075-1081
Number of pages7
JournalBone Marrow Transplantation
Volume47
Issue number8
DOIs
Publication statusPublished - Aug 1 2012

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All Science Journal Classification (ASJC) codes

  • Hematology
  • Transplantation

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