Validation of the CBF, CBV, and MTT Values by Perfusion MRI in Chronic Occlusive Cerebrovascular Disease: A Comparison with 15O-PET

Koichiro Kaneko, Yasuo Kuwabara, Futoshi Mihara, Takashi Yoshiura, Makoto Nakagawa, Atsuo Tanaka, Masayuki Sasaki, Hirofumi Koga, Kazutaka Hayashi, Hiroshi Honda

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Abstract

Rationale and Objectives. To evaluate the reliability of cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT) values obtained by deconvolution algorithm perfusion-weighted MR imaging (D-PWI), we compared these values with those obtained by first-moment algorithm perfusion-weighted MR imaging (F-PWI) and 15O-PET. Subjects and Methods. Six healthy volunteers and eleven patients with chronic occlusive cerebrovascular disease were studied with both perfusion-weighted MR imaging and 15O-PET, and region-of-interest analyses were performed. Normalization factors for CBF and CBV values obtained by D-PWI were determined as the mean values of 15O-PET divided by those of D-PWI in healthy volunteers. Then these values were used in analyzing the data of the patients. Results. The MTT value obtained by D-PWI was 6.1 ± 0.5 seconds on the non-occluded side, 6.4 ± 0.7 seconds on the minimally to moderately stenosed side, and 6.7 ± 1.2 seconds on the severely stenosed to occluded side. These values were significantly correlated with those obtained by F-PWI (r = 0.83; P < .001), and with those obtained by 15O-PET (r = 0.78; P < .05). However, the CBF and CBV values obtained by D-PWI did not correlate with those obtained by 15O-PET. Conclusion. MTT values obtained by D-PWI were reliable parameters of cerebral hemodynamics, but the CBF and CBV values obtained by D-PWI were not always reliable.

Original languageEnglish
Pages (from-to)489-497
Number of pages9
JournalAcademic Radiology
Volume11
Issue number5
DOIs
Publication statusPublished - Jan 1 2004

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Cerebrovascular Circulation
Cerebrovascular Disorders
Perfusion
Healthy Volunteers
Cerebral Blood Volume

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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Validation of the CBF, CBV, and MTT Values by Perfusion MRI in Chronic Occlusive Cerebrovascular Disease : A Comparison with 15O-PET. / Kaneko, Koichiro; Kuwabara, Yasuo; Mihara, Futoshi; Yoshiura, Takashi; Nakagawa, Makoto; Tanaka, Atsuo; Sasaki, Masayuki; Koga, Hirofumi; Hayashi, Kazutaka; Honda, Hiroshi.

In: Academic Radiology, Vol. 11, No. 5, 01.01.2004, p. 489-497.

Research output: Contribution to journalArticle

Kaneko, K, Kuwabara, Y, Mihara, F, Yoshiura, T, Nakagawa, M, Tanaka, A, Sasaki, M, Koga, H, Hayashi, K & Honda, H 2004, 'Validation of the CBF, CBV, and MTT Values by Perfusion MRI in Chronic Occlusive Cerebrovascular Disease: A Comparison with 15O-PET', Academic Radiology, vol. 11, no. 5, pp. 489-497. https://doi.org/10.1016/S1076-6332(03)00722-0
Kaneko, Koichiro ; Kuwabara, Yasuo ; Mihara, Futoshi ; Yoshiura, Takashi ; Nakagawa, Makoto ; Tanaka, Atsuo ; Sasaki, Masayuki ; Koga, Hirofumi ; Hayashi, Kazutaka ; Honda, Hiroshi. / Validation of the CBF, CBV, and MTT Values by Perfusion MRI in Chronic Occlusive Cerebrovascular Disease : A Comparison with 15O-PET. In: Academic Radiology. 2004 ; Vol. 11, No. 5. pp. 489-497.
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abstract = "Rationale and Objectives. To evaluate the reliability of cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT) values obtained by deconvolution algorithm perfusion-weighted MR imaging (D-PWI), we compared these values with those obtained by first-moment algorithm perfusion-weighted MR imaging (F-PWI) and 15O-PET. Subjects and Methods. Six healthy volunteers and eleven patients with chronic occlusive cerebrovascular disease were studied with both perfusion-weighted MR imaging and 15O-PET, and region-of-interest analyses were performed. Normalization factors for CBF and CBV values obtained by D-PWI were determined as the mean values of 15O-PET divided by those of D-PWI in healthy volunteers. Then these values were used in analyzing the data of the patients. Results. The MTT value obtained by D-PWI was 6.1 ± 0.5 seconds on the non-occluded side, 6.4 ± 0.7 seconds on the minimally to moderately stenosed side, and 6.7 ± 1.2 seconds on the severely stenosed to occluded side. These values were significantly correlated with those obtained by F-PWI (r = 0.83; P < .001), and with those obtained by 15O-PET (r = 0.78; P < .05). However, the CBF and CBV values obtained by D-PWI did not correlate with those obtained by 15O-PET. Conclusion. MTT values obtained by D-PWI were reliable parameters of cerebral hemodynamics, but the CBF and CBV values obtained by D-PWI were not always reliable.",
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T1 - Validation of the CBF, CBV, and MTT Values by Perfusion MRI in Chronic Occlusive Cerebrovascular Disease

T2 - A Comparison with 15O-PET

AU - Kaneko, Koichiro

AU - Kuwabara, Yasuo

AU - Mihara, Futoshi

AU - Yoshiura, Takashi

AU - Nakagawa, Makoto

AU - Tanaka, Atsuo

AU - Sasaki, Masayuki

AU - Koga, Hirofumi

AU - Hayashi, Kazutaka

AU - Honda, Hiroshi

PY - 2004/1/1

Y1 - 2004/1/1

N2 - Rationale and Objectives. To evaluate the reliability of cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT) values obtained by deconvolution algorithm perfusion-weighted MR imaging (D-PWI), we compared these values with those obtained by first-moment algorithm perfusion-weighted MR imaging (F-PWI) and 15O-PET. Subjects and Methods. Six healthy volunteers and eleven patients with chronic occlusive cerebrovascular disease were studied with both perfusion-weighted MR imaging and 15O-PET, and region-of-interest analyses were performed. Normalization factors for CBF and CBV values obtained by D-PWI were determined as the mean values of 15O-PET divided by those of D-PWI in healthy volunteers. Then these values were used in analyzing the data of the patients. Results. The MTT value obtained by D-PWI was 6.1 ± 0.5 seconds on the non-occluded side, 6.4 ± 0.7 seconds on the minimally to moderately stenosed side, and 6.7 ± 1.2 seconds on the severely stenosed to occluded side. These values were significantly correlated with those obtained by F-PWI (r = 0.83; P < .001), and with those obtained by 15O-PET (r = 0.78; P < .05). However, the CBF and CBV values obtained by D-PWI did not correlate with those obtained by 15O-PET. Conclusion. MTT values obtained by D-PWI were reliable parameters of cerebral hemodynamics, but the CBF and CBV values obtained by D-PWI were not always reliable.

AB - Rationale and Objectives. To evaluate the reliability of cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT) values obtained by deconvolution algorithm perfusion-weighted MR imaging (D-PWI), we compared these values with those obtained by first-moment algorithm perfusion-weighted MR imaging (F-PWI) and 15O-PET. Subjects and Methods. Six healthy volunteers and eleven patients with chronic occlusive cerebrovascular disease were studied with both perfusion-weighted MR imaging and 15O-PET, and region-of-interest analyses were performed. Normalization factors for CBF and CBV values obtained by D-PWI were determined as the mean values of 15O-PET divided by those of D-PWI in healthy volunteers. Then these values were used in analyzing the data of the patients. Results. The MTT value obtained by D-PWI was 6.1 ± 0.5 seconds on the non-occluded side, 6.4 ± 0.7 seconds on the minimally to moderately stenosed side, and 6.7 ± 1.2 seconds on the severely stenosed to occluded side. These values were significantly correlated with those obtained by F-PWI (r = 0.83; P < .001), and with those obtained by 15O-PET (r = 0.78; P < .05). However, the CBF and CBV values obtained by D-PWI did not correlate with those obtained by 15O-PET. Conclusion. MTT values obtained by D-PWI were reliable parameters of cerebral hemodynamics, but the CBF and CBV values obtained by D-PWI were not always reliable.

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