Validation of the CBF, CBV, and MTT Values by Perfusion MRI in Chronic Occlusive Cerebrovascular Disease: A Comparison with 15O-PET

Koichiro Kaneko, Yasuo Kuwabara, Futoshi Mihara, Takashi Yoshiura, Makoto Nakagawa, Atsuo Tanaka, Masayuki Sasaki, Hirofumi Koga, Kazutaka Hayashi, Hiroshi Honda

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Abstract

Rationale and Objectives. To evaluate the reliability of cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT) values obtained by deconvolution algorithm perfusion-weighted MR imaging (D-PWI), we compared these values with those obtained by first-moment algorithm perfusion-weighted MR imaging (F-PWI) and 15O-PET. Subjects and Methods. Six healthy volunteers and eleven patients with chronic occlusive cerebrovascular disease were studied with both perfusion-weighted MR imaging and 15O-PET, and region-of-interest analyses were performed. Normalization factors for CBF and CBV values obtained by D-PWI were determined as the mean values of 15O-PET divided by those of D-PWI in healthy volunteers. Then these values were used in analyzing the data of the patients. Results. The MTT value obtained by D-PWI was 6.1 ± 0.5 seconds on the non-occluded side, 6.4 ± 0.7 seconds on the minimally to moderately stenosed side, and 6.7 ± 1.2 seconds on the severely stenosed to occluded side. These values were significantly correlated with those obtained by F-PWI (r = 0.83; P < .001), and with those obtained by 15O-PET (r = 0.78; P < .05). However, the CBF and CBV values obtained by D-PWI did not correlate with those obtained by 15O-PET. Conclusion. MTT values obtained by D-PWI were reliable parameters of cerebral hemodynamics, but the CBF and CBV values obtained by D-PWI were not always reliable.

Original languageEnglish
Pages (from-to)489-497
Number of pages9
JournalAcademic Radiology
Volume11
Issue number5
DOIs
Publication statusPublished - May 2004

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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    Kaneko, K., Kuwabara, Y., Mihara, F., Yoshiura, T., Nakagawa, M., Tanaka, A., Sasaki, M., Koga, H., Hayashi, K., & Honda, H. (2004). Validation of the CBF, CBV, and MTT Values by Perfusion MRI in Chronic Occlusive Cerebrovascular Disease: A Comparison with 15O-PET. Academic Radiology, 11(5), 489-497. https://doi.org/10.1016/S1076-6332(03)00722-0