Validity of image-defined risk factors in localized neuroblastoma: A report from two centers in Western Japan

Shigehisa Fumino, Koseki Kimura, Tomoko Iehara, Motoki Nishimura, Satoaki Nakamura, Ryota Sozaki, Akihiro Nishie, Tomoaki Taguchi, Hajime Hosoi, Tatsuro Tajiri

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Abstract

Background Japanese Neuroblastoma Study Group (JNBSG) has been employing image-defined risk factors (IDRFs) since 2010. However, the report from INRG in 2011 supplemented description stating that isolated contact is considered to be IDRF-positive only in renal vessels. The aim of this study was to evaluate the validity of IDRFs by comparing the previous (PG) and new guidelines (NG). Methods IDRFs of patients with localized neuroblastoma treated at two centers in Western Japan from 2002 to 2013 were retrospectively reviewed by radiologists. Results 47 neuroblastomas (abdomen 38, pelvis 2, mediastinum 7) were evaluated. For abdominal neuroblastomas, IDRFs were present in 15/38 (39.5%) using PG and in 31/38 (81.6%) using NG. Moreover, the IDRF-positive rate increased from 26.7% (4/15) to 80.0% (12/15) in 15 cases diagnosed during mass screening. Of the IDRF-positive cases, complete primary resection was achieved in 2/15 (13.3%) using PG and 17/31 patients (54.8%) using NG. There were two major surgical renal complications in the IDRF-positive cases based on the use of either guidelines, and the specificity decreased from 64% to 19%. Conclusions According to NG, the IDRF-positive rate increased, and the resection rate decreased. NG may overestimate surgical risks, leading to unnecessary chemotherapy and a prolonged hospital stay.

Original languageEnglish
Pages (from-to)2102-2106
Number of pages5
JournalJournal of Pediatric Surgery
Volume50
Issue number12
DOIs
Publication statusPublished - Jan 1 2015

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Neuroblastoma
Japan
Guidelines
Kidney
Mass Screening
Mediastinum
Pelvis
Abdomen
Length of Stay
Drug Therapy

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pediatrics, Perinatology, and Child Health

Cite this

Fumino, S., Kimura, K., Iehara, T., Nishimura, M., Nakamura, S., Sozaki, R., ... Tajiri, T. (2015). Validity of image-defined risk factors in localized neuroblastoma: A report from two centers in Western Japan. Journal of Pediatric Surgery, 50(12), 2102-2106. https://doi.org/10.1016/j.jpedsurg.2015.08.039

Validity of image-defined risk factors in localized neuroblastoma : A report from two centers in Western Japan. / Fumino, Shigehisa; Kimura, Koseki; Iehara, Tomoko; Nishimura, Motoki; Nakamura, Satoaki; Sozaki, Ryota; Nishie, Akihiro; Taguchi, Tomoaki; Hosoi, Hajime; Tajiri, Tatsuro.

In: Journal of Pediatric Surgery, Vol. 50, No. 12, 01.01.2015, p. 2102-2106.

Research output: Contribution to journalArticle

Fumino, Shigehisa ; Kimura, Koseki ; Iehara, Tomoko ; Nishimura, Motoki ; Nakamura, Satoaki ; Sozaki, Ryota ; Nishie, Akihiro ; Taguchi, Tomoaki ; Hosoi, Hajime ; Tajiri, Tatsuro. / Validity of image-defined risk factors in localized neuroblastoma : A report from two centers in Western Japan. In: Journal of Pediatric Surgery. 2015 ; Vol. 50, No. 12. pp. 2102-2106.
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abstract = "Background Japanese Neuroblastoma Study Group (JNBSG) has been employing image-defined risk factors (IDRFs) since 2010. However, the report from INRG in 2011 supplemented description stating that isolated contact is considered to be IDRF-positive only in renal vessels. The aim of this study was to evaluate the validity of IDRFs by comparing the previous (PG) and new guidelines (NG). Methods IDRFs of patients with localized neuroblastoma treated at two centers in Western Japan from 2002 to 2013 were retrospectively reviewed by radiologists. Results 47 neuroblastomas (abdomen 38, pelvis 2, mediastinum 7) were evaluated. For abdominal neuroblastomas, IDRFs were present in 15/38 (39.5{\%}) using PG and in 31/38 (81.6{\%}) using NG. Moreover, the IDRF-positive rate increased from 26.7{\%} (4/15) to 80.0{\%} (12/15) in 15 cases diagnosed during mass screening. Of the IDRF-positive cases, complete primary resection was achieved in 2/15 (13.3{\%}) using PG and 17/31 patients (54.8{\%}) using NG. There were two major surgical renal complications in the IDRF-positive cases based on the use of either guidelines, and the specificity decreased from 64{\%} to 19{\%}. Conclusions According to NG, the IDRF-positive rate increased, and the resection rate decreased. NG may overestimate surgical risks, leading to unnecessary chemotherapy and a prolonged hospital stay.",
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AU - Fumino, Shigehisa

AU - Kimura, Koseki

AU - Iehara, Tomoko

AU - Nishimura, Motoki

AU - Nakamura, Satoaki

AU - Sozaki, Ryota

AU - Nishie, Akihiro

AU - Taguchi, Tomoaki

AU - Hosoi, Hajime

AU - Tajiri, Tatsuro

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N2 - Background Japanese Neuroblastoma Study Group (JNBSG) has been employing image-defined risk factors (IDRFs) since 2010. However, the report from INRG in 2011 supplemented description stating that isolated contact is considered to be IDRF-positive only in renal vessels. The aim of this study was to evaluate the validity of IDRFs by comparing the previous (PG) and new guidelines (NG). Methods IDRFs of patients with localized neuroblastoma treated at two centers in Western Japan from 2002 to 2013 were retrospectively reviewed by radiologists. Results 47 neuroblastomas (abdomen 38, pelvis 2, mediastinum 7) were evaluated. For abdominal neuroblastomas, IDRFs were present in 15/38 (39.5%) using PG and in 31/38 (81.6%) using NG. Moreover, the IDRF-positive rate increased from 26.7% (4/15) to 80.0% (12/15) in 15 cases diagnosed during mass screening. Of the IDRF-positive cases, complete primary resection was achieved in 2/15 (13.3%) using PG and 17/31 patients (54.8%) using NG. There were two major surgical renal complications in the IDRF-positive cases based on the use of either guidelines, and the specificity decreased from 64% to 19%. Conclusions According to NG, the IDRF-positive rate increased, and the resection rate decreased. NG may overestimate surgical risks, leading to unnecessary chemotherapy and a prolonged hospital stay.

AB - Background Japanese Neuroblastoma Study Group (JNBSG) has been employing image-defined risk factors (IDRFs) since 2010. However, the report from INRG in 2011 supplemented description stating that isolated contact is considered to be IDRF-positive only in renal vessels. The aim of this study was to evaluate the validity of IDRFs by comparing the previous (PG) and new guidelines (NG). Methods IDRFs of patients with localized neuroblastoma treated at two centers in Western Japan from 2002 to 2013 were retrospectively reviewed by radiologists. Results 47 neuroblastomas (abdomen 38, pelvis 2, mediastinum 7) were evaluated. For abdominal neuroblastomas, IDRFs were present in 15/38 (39.5%) using PG and in 31/38 (81.6%) using NG. Moreover, the IDRF-positive rate increased from 26.7% (4/15) to 80.0% (12/15) in 15 cases diagnosed during mass screening. Of the IDRF-positive cases, complete primary resection was achieved in 2/15 (13.3%) using PG and 17/31 patients (54.8%) using NG. There were two major surgical renal complications in the IDRF-positive cases based on the use of either guidelines, and the specificity decreased from 64% to 19%. Conclusions According to NG, the IDRF-positive rate increased, and the resection rate decreased. NG may overestimate surgical risks, leading to unnecessary chemotherapy and a prolonged hospital stay.

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