Value of virtual touch quantification elastography for assessing liver congestion in patients with heart failure

Takashi Yoshitani, Naoya Asakawa, Mamoru Sakakibara, Keiji Noguchi, Yusuke Tokuda, Kiwamu Kamiya, Hiroyuki Iwano, Satoshi Yamada, Yusuke Kudou, Mutsumi Nishida, Chikara Shimizu, Toraji Amano, Hiroyuki Tsutsui

Research output: Contribution to journalArticle

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Abstract

Background: Heart failure (HF) causes organ congestion, which is thought to increase organ stiffness. The virtual touch quantification (VTQ) method can be used to assess liver stiffness in patients with chronic liver diseases. This study aimed to measure liver and kidney stiffness using VTQ and to determine its value for assessing organ congestion in patients with HF. Methods and Results: This study included 10 normal subjects and 38 HF patients (age 52.3±16.7 years, left ventricular ejection fraction 27.0±9.4%, plasma B-type natriuretic peptide [BNP] 1,297.3±1,155.1 pg/ml). We investigated the relationships between clinical characteristics and hemodynamics and liver and kidney stiffness, and assessed the effects of medical treatment on these measurements. Liver stiffness was significantly higher in HF patients (1.17±0.13 m/s vs. 2.03±0.91 m/s, P=0.004) compared with normal subjects, but kidney stiffness was similar in both groups. Central venous pressure (CVP) (P=0.021) and BNP (P=0.025) were independent predictive factors for increased liver stiffness in HF patients. Liver stiffness decreased significantly from 2.37±1.09 to 1.27±0.33 m/s (P<0.001) after treatment. Changes in liver stiffness in HF patients significantly correlated with changes in CVP (R=0.636, P=0.014) and cardiac index (R=−0.557, P=0.039) according to univariate analysis, and with changes in CVP in multivariate analysis. Conclusions: Liver stiffness measured by noninvasive VTQ methods can be used to assess liver congestion and therapeutic effects in patients with HF.

Original languageEnglish
Pages (from-to)1187-1195
Number of pages9
JournalCirculation Journal
Volume80
Issue number5
DOIs
Publication statusPublished - Jan 1 2016

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Elasticity Imaging Techniques
Touch
Heart Failure
Liver
Central Venous Pressure
Brain Natriuretic Peptide
Kidney
Therapeutic Uses
Stroke Volume
Liver Diseases
Chronic Disease
Multivariate Analysis
Hemodynamics

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Value of virtual touch quantification elastography for assessing liver congestion in patients with heart failure. / Yoshitani, Takashi; Asakawa, Naoya; Sakakibara, Mamoru; Noguchi, Keiji; Tokuda, Yusuke; Kamiya, Kiwamu; Iwano, Hiroyuki; Yamada, Satoshi; Kudou, Yusuke; Nishida, Mutsumi; Shimizu, Chikara; Amano, Toraji; Tsutsui, Hiroyuki.

In: Circulation Journal, Vol. 80, No. 5, 01.01.2016, p. 1187-1195.

Research output: Contribution to journalArticle

Yoshitani, T, Asakawa, N, Sakakibara, M, Noguchi, K, Tokuda, Y, Kamiya, K, Iwano, H, Yamada, S, Kudou, Y, Nishida, M, Shimizu, C, Amano, T & Tsutsui, H 2016, 'Value of virtual touch quantification elastography for assessing liver congestion in patients with heart failure', Circulation Journal, vol. 80, no. 5, pp. 1187-1195. https://doi.org/10.1253/circj.CJ-15-1200
Yoshitani, Takashi ; Asakawa, Naoya ; Sakakibara, Mamoru ; Noguchi, Keiji ; Tokuda, Yusuke ; Kamiya, Kiwamu ; Iwano, Hiroyuki ; Yamada, Satoshi ; Kudou, Yusuke ; Nishida, Mutsumi ; Shimizu, Chikara ; Amano, Toraji ; Tsutsui, Hiroyuki. / Value of virtual touch quantification elastography for assessing liver congestion in patients with heart failure. In: Circulation Journal. 2016 ; Vol. 80, No. 5. pp. 1187-1195.
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abstract = "Background: Heart failure (HF) causes organ congestion, which is thought to increase organ stiffness. The virtual touch quantification (VTQ) method can be used to assess liver stiffness in patients with chronic liver diseases. This study aimed to measure liver and kidney stiffness using VTQ and to determine its value for assessing organ congestion in patients with HF. Methods and Results: This study included 10 normal subjects and 38 HF patients (age 52.3±16.7 years, left ventricular ejection fraction 27.0±9.4{\%}, plasma B-type natriuretic peptide [BNP] 1,297.3±1,155.1 pg/ml). We investigated the relationships between clinical characteristics and hemodynamics and liver and kidney stiffness, and assessed the effects of medical treatment on these measurements. Liver stiffness was significantly higher in HF patients (1.17±0.13 m/s vs. 2.03±0.91 m/s, P=0.004) compared with normal subjects, but kidney stiffness was similar in both groups. Central venous pressure (CVP) (P=0.021) and BNP (P=0.025) were independent predictive factors for increased liver stiffness in HF patients. Liver stiffness decreased significantly from 2.37±1.09 to 1.27±0.33 m/s (P<0.001) after treatment. Changes in liver stiffness in HF patients significantly correlated with changes in CVP (R=0.636, P=0.014) and cardiac index (R=−0.557, P=0.039) according to univariate analysis, and with changes in CVP in multivariate analysis. Conclusions: Liver stiffness measured by noninvasive VTQ methods can be used to assess liver congestion and therapeutic effects in patients with HF.",
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AU - Yoshitani, Takashi

AU - Asakawa, Naoya

AU - Sakakibara, Mamoru

AU - Noguchi, Keiji

AU - Tokuda, Yusuke

AU - Kamiya, Kiwamu

AU - Iwano, Hiroyuki

AU - Yamada, Satoshi

AU - Kudou, Yusuke

AU - Nishida, Mutsumi

AU - Shimizu, Chikara

AU - Amano, Toraji

AU - Tsutsui, Hiroyuki

PY - 2016/1/1

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N2 - Background: Heart failure (HF) causes organ congestion, which is thought to increase organ stiffness. The virtual touch quantification (VTQ) method can be used to assess liver stiffness in patients with chronic liver diseases. This study aimed to measure liver and kidney stiffness using VTQ and to determine its value for assessing organ congestion in patients with HF. Methods and Results: This study included 10 normal subjects and 38 HF patients (age 52.3±16.7 years, left ventricular ejection fraction 27.0±9.4%, plasma B-type natriuretic peptide [BNP] 1,297.3±1,155.1 pg/ml). We investigated the relationships between clinical characteristics and hemodynamics and liver and kidney stiffness, and assessed the effects of medical treatment on these measurements. Liver stiffness was significantly higher in HF patients (1.17±0.13 m/s vs. 2.03±0.91 m/s, P=0.004) compared with normal subjects, but kidney stiffness was similar in both groups. Central venous pressure (CVP) (P=0.021) and BNP (P=0.025) were independent predictive factors for increased liver stiffness in HF patients. Liver stiffness decreased significantly from 2.37±1.09 to 1.27±0.33 m/s (P<0.001) after treatment. Changes in liver stiffness in HF patients significantly correlated with changes in CVP (R=0.636, P=0.014) and cardiac index (R=−0.557, P=0.039) according to univariate analysis, and with changes in CVP in multivariate analysis. Conclusions: Liver stiffness measured by noninvasive VTQ methods can be used to assess liver congestion and therapeutic effects in patients with HF.

AB - Background: Heart failure (HF) causes organ congestion, which is thought to increase organ stiffness. The virtual touch quantification (VTQ) method can be used to assess liver stiffness in patients with chronic liver diseases. This study aimed to measure liver and kidney stiffness using VTQ and to determine its value for assessing organ congestion in patients with HF. Methods and Results: This study included 10 normal subjects and 38 HF patients (age 52.3±16.7 years, left ventricular ejection fraction 27.0±9.4%, plasma B-type natriuretic peptide [BNP] 1,297.3±1,155.1 pg/ml). We investigated the relationships between clinical characteristics and hemodynamics and liver and kidney stiffness, and assessed the effects of medical treatment on these measurements. Liver stiffness was significantly higher in HF patients (1.17±0.13 m/s vs. 2.03±0.91 m/s, P=0.004) compared with normal subjects, but kidney stiffness was similar in both groups. Central venous pressure (CVP) (P=0.021) and BNP (P=0.025) were independent predictive factors for increased liver stiffness in HF patients. Liver stiffness decreased significantly from 2.37±1.09 to 1.27±0.33 m/s (P<0.001) after treatment. Changes in liver stiffness in HF patients significantly correlated with changes in CVP (R=0.636, P=0.014) and cardiac index (R=−0.557, P=0.039) according to univariate analysis, and with changes in CVP in multivariate analysis. Conclusions: Liver stiffness measured by noninvasive VTQ methods can be used to assess liver congestion and therapeutic effects in patients with HF.

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