Variants of endothelin-1 and its receptors in atopic asthma

Xiao Quan Mao, Pei Song Gao, Mark H. Roberts, Tadao Enomoto, Mitsuru Kawai, Sei Sasaki, Sarah R. Shaldon, Phillip Coull, Yasuhiro Dake, Chaker N. Adra, Akihito Hagihara, Taro Shirakawa, Julian M. Hopkin

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Abstract

Endothelin-1 (ET-1) is a 21 amino acid peptide released from several types of bronchial cells. It operates through two types of receptors, type A(ET-RA) and type B(ET-RB) and has various activities in the pathophysiology of atopic asthma. These genes are localised on different chromosomes where genomewide searches have identified linkage for atopic asthma, thus supporting the candidacy of ET-1 and its receptors for atopic asthma. A genetic association study was performed with variants of these three genes in both British (n = 300) and Japanese populations (n = 200). No significant association was found between variants of EDN1 and EDNRB genes, and atopic asthma in either population. However variants of EDNRA gene showed a marginal association with atopy [odds = 0.39(95% CI: 0.17-0.89), p = 0.022, Pc = 0.066], especially with antigen specific IgE levels [odds = 0.31 (95% CI: 0.20-0.77), p = 0.006, Pc = 0.018] in the British population. These findings suggest that EDNRA is a major candidate locus for atopy on chromosome 4.

Original languageEnglish
Pages (from-to)259-262
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume262
Issue number1
DOIs
Publication statusPublished - Aug 19 1999

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Mao, X. Q., Gao, P. S., Roberts, M. H., Enomoto, T., Kawai, M., Sasaki, S., Shaldon, S. R., Coull, P., Dake, Y., Adra, C. N., Hagihara, A., Shirakawa, T., & Hopkin, J. M. (1999). Variants of endothelin-1 and its receptors in atopic asthma. Biochemical and Biophysical Research Communications, 262(1), 259-262. https://doi.org/10.1006/bbrc.1999.1158