TY - JOUR
T1 - Variation in half-life of penta-chlorodibenzofuran (PeCDF) blood level among Yusho patients
AU - Matsumoto, Shinya
AU - Akahane, Manabu
AU - Kanagawa, Yoshiyuki
AU - Koike, Soichi
AU - Yoshimura, Takesumi
AU - Mitoma, Chikage
AU - Shibata, Satoko
AU - Uchi, Hiroshi
AU - Furue, Masutaka
AU - Imamura, Tomoaki
N1 - Funding Information:
This study was supported by a Grant-in-Aid for scientific research from the Ministry of Health, Labour and Welfare, Japan ( Research on Food Safety , H18-012 ).
PY - 2009/10
Y1 - 2009/10
N2 - Yusho (oil disease) is the name given to a food poisoning incident caused by rice bran oil that occurred in west Japan in 1968. The causative agents of Yusho are currently considered to be polychlorinated biphenyls (PCBs) and their by-products, such as dioxin like compounds. The levels of 2,3,4,7,8-penta-cholorodibenzofuran (PeCDF) are measured in the blood of Yusho patients who attend medical check-ups. The objectives of this study were to determine the half-life of PeCDF in these patients. Linear regression analysis was performed with the binary logarithm of PeCDF blood levels in Yusho patients as the dependent variable and the measurement year as the independent variable. The linear coefficient determined in this analysis is the reciprocal of the half-life. The half-life of PeCDF varied among patients. Among patients with PeCDF blood levels of 50 pg g-1 or higher, there were two groups: one showing a half-life of approximately 7 years and the other showing no reduction in PeCDF levels over time. The results indicate that there is a group of patients whose PeCDF levels are maintained at a high level. Our study suggests that a more complicated model is required to explain PeCDF excretion in humans.
AB - Yusho (oil disease) is the name given to a food poisoning incident caused by rice bran oil that occurred in west Japan in 1968. The causative agents of Yusho are currently considered to be polychlorinated biphenyls (PCBs) and their by-products, such as dioxin like compounds. The levels of 2,3,4,7,8-penta-cholorodibenzofuran (PeCDF) are measured in the blood of Yusho patients who attend medical check-ups. The objectives of this study were to determine the half-life of PeCDF in these patients. Linear regression analysis was performed with the binary logarithm of PeCDF blood levels in Yusho patients as the dependent variable and the measurement year as the independent variable. The linear coefficient determined in this analysis is the reciprocal of the half-life. The half-life of PeCDF varied among patients. Among patients with PeCDF blood levels of 50 pg g-1 or higher, there were two groups: one showing a half-life of approximately 7 years and the other showing no reduction in PeCDF levels over time. The results indicate that there is a group of patients whose PeCDF levels are maintained at a high level. Our study suggests that a more complicated model is required to explain PeCDF excretion in humans.
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U2 - 10.1016/j.chemosphere.2009.08.009
DO - 10.1016/j.chemosphere.2009.08.009
M3 - Article
C2 - 19748112
AN - SCOPUS:70349432166
SN - 0045-6535
VL - 77
SP - 658
EP - 662
JO - Chemosphere
JF - Chemosphere
IS - 5
ER -