Varicella-zoster virus symptoms and polyneuropathy in a patient with human immunodeficiency virus infection not improved until highly active anti-retroviral therapy added to acyclovir therapy

Hiroaki Takeoka, Yong Jeong, Murata Masayuki, Norihiro Furusyo, Shigeki Nabeshima, Kouzaburo Yamaji, Yasuhiro Kishihara, Jun Hayashi

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Abstract

In March 2003, a 34-year-old man with left facial palsy, dysphagia, and hoarseness treated with acyclovir suffered worsened dermatological and neurological problems. A routine blood test in early April showed the patient to be HIV-antibody positive, so he was transferred to our hospital. Blood analysis showed serum HIV-RNA at 96,000 copies/mL and a CD 4 count of 170/microL. Brain MRI taken on admission showed a T 2 high lesion in their left medulla. Acyclovir was thought to be ineffective due to reduced cell-mediated immunity because of the HIV infection, and HAART therapy was begun. After two months of HAART, skin lesions and the T 2 high lesion in left medulla improred. HIV-RNA became undetectable and the CD 4 count exceeded 500/microL. Intracellular cytokine analysis by flow cytometry showed a shift from Th 2 to Th 1 dominance. The elimination of VZV may thus have been promoted by the combination of acyclovir and HAART.

Original languageEnglish
Pages (from-to)46-50
Number of pages5
JournalKansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases
Volume80
Issue number1
DOIs
Publication statusPublished - Jan 1 2006

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Human Herpesvirus 3
Acyclovir
Polyneuropathies
Highly Active Antiretroviral Therapy
Virus Diseases
HIV
RNA
Hoarseness
HIV Antibodies
Facial Paralysis
Hematologic Tests
Deglutition Disorders
Cellular Immunity
HIV Infections
Flow Cytometry
Therapeutics
Cytokines
Skin
Brain
Serum

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Varicella-zoster virus symptoms and polyneuropathy in a patient with human immunodeficiency virus infection not improved until highly active anti-retroviral therapy added to acyclovir therapy. / Takeoka, Hiroaki; Jeong, Yong; Masayuki, Murata; Furusyo, Norihiro; Nabeshima, Shigeki; Yamaji, Kouzaburo; Kishihara, Yasuhiro; Hayashi, Jun.

In: Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases, Vol. 80, No. 1, 01.01.2006, p. 46-50.

Research output: Contribution to journalArticle

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