Vascular endothelial growth factor and malignant transformation of a meningioma: Case report

Tadahisa Shono, Takanori Inamura, Miho Torisu, Satoshi Suzuki, Masashi Fukui

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Although meningiomas are common benign intracranial tumors which grow slowly, we occasionally encountered aggressive or malignant ones. One of these cases showed an interesting relationship to vascular endothelial growth factor (VEGF). A 39-year-old woman underwent resection of a sphenoid ridge meningioma; the residual tumor showed evidence of malignant transformation 14 years later. We immunohistochemically examined six successive surgical specimens plus the autopsy specimen of this patient's tumor for proliferative potential, vascularity, and expression of various growth factors. In the latter stage of clinical courses, proliferative potential and vascularity was seen to increase year by year. Expression of VEGF was upregulated and correlated with vascularity. On the other hand, basic fibroblast growth factor (bFGF), platelet-derived growth factor (PDGF), and epidermal growth factor (EGF) were not overexpressed in this tumor. This case suggests that overexpression of VEGF and increased angiogenic potential might be involved in malignant transformation of meningiomas.

Original languageEnglish
Pages (from-to)189-193
Number of pages5
JournalNeurological Research
Volume22
Issue number2
DOIs
Publication statusPublished - Jan 1 2000

Fingerprint

Meningioma
Vascular Endothelial Growth Factor A
Neoplasms
Platelet-Derived Growth Factor
Residual Neoplasm
Fibroblast Growth Factor 2
Epidermal Growth Factor
Autopsy
Intercellular Signaling Peptides and Proteins

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Vascular endothelial growth factor and malignant transformation of a meningioma : Case report. / Shono, Tadahisa; Inamura, Takanori; Torisu, Miho; Suzuki, Satoshi; Fukui, Masashi.

In: Neurological Research, Vol. 22, No. 2, 01.01.2000, p. 189-193.

Research output: Contribution to journalArticle

Shono, Tadahisa ; Inamura, Takanori ; Torisu, Miho ; Suzuki, Satoshi ; Fukui, Masashi. / Vascular endothelial growth factor and malignant transformation of a meningioma : Case report. In: Neurological Research. 2000 ; Vol. 22, No. 2. pp. 189-193.
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