Abstract
Objective. To elucidate molecular aspects of the mechanisms of expansion of chronic subdural haematomas (CSH), we examined the expression of two representative angiogenic factors, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in CSH. Methods. We quantified VEGF and bFGF in haematoma fluid and serum of 20 patients with CSH using an enzyme-linked immunosorbent assay. Mean concentrations of VEGF in the haematoma fluid (10277 pg/ml) and in serum, (355 pg/ml) were much greater than those of bFGF (haematoma, 3.04 pg/ml; serum, 4.74 pg/ml). Surgical specimens, including dura and the outer membrane of the CSH were analysed by in situ hybridisation to detect VEGF mRNA. Macrophages and vascular endothelial cells in the outer membrane over expressed VEGF mRNA. Conclusions. Enhanced production of VEGF by macrophages and vascular endothelial cells in the outer membrane is thought to be pathogenetically important in CSH.
| Original language | English |
|---|---|
| Pages (from-to) | 411-415 |
| Number of pages | 5 |
| Journal | Journal of Clinical Neuroscience |
| Volume | 8 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Jan 1 2001 |
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All Science Journal Classification (ASJC) codes
- Neurology
- Clinical Neurology
- Physiology (medical)
Cite this
Vascular endothelial growth factor in chronic subdural haematomas. / Shono, Tadahisa; Inamura, Takanori; Morioka, Takato; Matsumoto, Ken ichi; Suzuki, Satoshi; Ikezaki, Kiyonobu; Iwaki, Toru; Fukui, Masashi.
In: Journal of Clinical Neuroscience, Vol. 8, No. 5, 01.01.2001, p. 411-415.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Vascular endothelial growth factor in chronic subdural haematomas
AU - Shono, Tadahisa
AU - Inamura, Takanori
AU - Morioka, Takato
AU - Matsumoto, Ken ichi
AU - Suzuki, Satoshi
AU - Ikezaki, Kiyonobu
AU - Iwaki, Toru
AU - Fukui, Masashi
PY - 2001/1/1
Y1 - 2001/1/1
N2 - Objective. To elucidate molecular aspects of the mechanisms of expansion of chronic subdural haematomas (CSH), we examined the expression of two representative angiogenic factors, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in CSH. Methods. We quantified VEGF and bFGF in haematoma fluid and serum of 20 patients with CSH using an enzyme-linked immunosorbent assay. Mean concentrations of VEGF in the haematoma fluid (10277 pg/ml) and in serum, (355 pg/ml) were much greater than those of bFGF (haematoma, 3.04 pg/ml; serum, 4.74 pg/ml). Surgical specimens, including dura and the outer membrane of the CSH were analysed by in situ hybridisation to detect VEGF mRNA. Macrophages and vascular endothelial cells in the outer membrane over expressed VEGF mRNA. Conclusions. Enhanced production of VEGF by macrophages and vascular endothelial cells in the outer membrane is thought to be pathogenetically important in CSH.
AB - Objective. To elucidate molecular aspects of the mechanisms of expansion of chronic subdural haematomas (CSH), we examined the expression of two representative angiogenic factors, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in CSH. Methods. We quantified VEGF and bFGF in haematoma fluid and serum of 20 patients with CSH using an enzyme-linked immunosorbent assay. Mean concentrations of VEGF in the haematoma fluid (10277 pg/ml) and in serum, (355 pg/ml) were much greater than those of bFGF (haematoma, 3.04 pg/ml; serum, 4.74 pg/ml). Surgical specimens, including dura and the outer membrane of the CSH were analysed by in situ hybridisation to detect VEGF mRNA. Macrophages and vascular endothelial cells in the outer membrane over expressed VEGF mRNA. Conclusions. Enhanced production of VEGF by macrophages and vascular endothelial cells in the outer membrane is thought to be pathogenetically important in CSH.
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UR - http://www.scopus.com/inward/citedby.url?scp=0034843727&partnerID=8YFLogxK
U2 - 10.1054/jocn.2000.0951
DO - 10.1054/jocn.2000.0951
M3 - Article
C2 - 11535006
AN - SCOPUS:0034843727
VL - 8
SP - 411
EP - 415
JO - Journal of Clinical Neuroscience
JF - Journal of Clinical Neuroscience
SN - 0967-5868
IS - 5
ER -