Vascular endothelial growth factor in chronic subdural haematomas

Tadahisa Shono, Takanori Inamura, Takato Morioka, Ken ichi Matsumoto, Satoshi Suzuki, Kiyonobu Ikezaki, Toru Iwaki, Masashi Fukui

Research output: Contribution to journalArticle

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Abstract

Objective. To elucidate molecular aspects of the mechanisms of expansion of chronic subdural haematomas (CSH), we examined the expression of two representative angiogenic factors, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in CSH. Methods. We quantified VEGF and bFGF in haematoma fluid and serum of 20 patients with CSH using an enzyme-linked immunosorbent assay. Mean concentrations of VEGF in the haematoma fluid (10277 pg/ml) and in serum, (355 pg/ml) were much greater than those of bFGF (haematoma, 3.04 pg/ml; serum, 4.74 pg/ml). Surgical specimens, including dura and the outer membrane of the CSH were analysed by in situ hybridisation to detect VEGF mRNA. Macrophages and vascular endothelial cells in the outer membrane over expressed VEGF mRNA. Conclusions. Enhanced production of VEGF by macrophages and vascular endothelial cells in the outer membrane is thought to be pathogenetically important in CSH.

Original languageEnglish
Pages (from-to)411-415
Number of pages5
JournalJournal of Clinical Neuroscience
Volume8
Issue number5
DOIs
Publication statusPublished - Jan 1 2001

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Hematoma, Subdural, Chronic
Vascular Endothelial Growth Factor A
Fibroblast Growth Factor 2
Hematoma
Membranes
Endothelial Cells
Serum
Macrophages
Messenger RNA
Angiogenesis Inducing Agents
In Situ Hybridization
Enzyme-Linked Immunosorbent Assay

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Physiology (medical)

Cite this

Shono, T., Inamura, T., Morioka, T., Matsumoto, K. I., Suzuki, S., Ikezaki, K., ... Fukui, M. (2001). Vascular endothelial growth factor in chronic subdural haematomas. Journal of Clinical Neuroscience, 8(5), 411-415. https://doi.org/10.1054/jocn.2000.0951

Vascular endothelial growth factor in chronic subdural haematomas. / Shono, Tadahisa; Inamura, Takanori; Morioka, Takato; Matsumoto, Ken ichi; Suzuki, Satoshi; Ikezaki, Kiyonobu; Iwaki, Toru; Fukui, Masashi.

In: Journal of Clinical Neuroscience, Vol. 8, No. 5, 01.01.2001, p. 411-415.

Research output: Contribution to journalArticle

Shono, T, Inamura, T, Morioka, T, Matsumoto, KI, Suzuki, S, Ikezaki, K, Iwaki, T & Fukui, M 2001, 'Vascular endothelial growth factor in chronic subdural haematomas', Journal of Clinical Neuroscience, vol. 8, no. 5, pp. 411-415. https://doi.org/10.1054/jocn.2000.0951
Shono, Tadahisa ; Inamura, Takanori ; Morioka, Takato ; Matsumoto, Ken ichi ; Suzuki, Satoshi ; Ikezaki, Kiyonobu ; Iwaki, Toru ; Fukui, Masashi. / Vascular endothelial growth factor in chronic subdural haematomas. In: Journal of Clinical Neuroscience. 2001 ; Vol. 8, No. 5. pp. 411-415.
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