Vascular endothelial growth factor plays a role in hyperpermeability of diabetic retinal vessels

Toshinori Murata, Tatsuro Ishibashi, Ahmad Khalil, Yasuaki Hata, Hiroshi Yoshikawa, Hajime Inomata

Research output: Contribution to journalArticlepeer-review

197 Citations (Scopus)

Abstract

In rat diabetic retinas, we immunohistochemically looked for vascular endothelial growth factor (VEGF) which is also known as vascular permeability factor (VPF). In nondiabetic retinas, VEGF immunoreactivity was weak and restricted to the nerve fiber and ganglion cell layers. On the other hand, in diabetic retinas, VEGF immunoreactivity was markedly increased and was observed in all layers of the retina, especially in the perivascular area. Hyperpermeability of these vessels was confirmed by immunohistochemically detecting extravasation of albumin. These findings indicate that vascular endothelial growth factor plays an important role in blood-retinal barrier breakdown in diabetic retinopathy.

Original languageEnglish
Pages (from-to)48-52
Number of pages5
JournalOphthalmic Research
Volume27
Issue number1
DOIs
Publication statusPublished - 1995

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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