Vascular remodeling and angiotensin II

M. Takemoto, K. Egashira

    Research output: Contribution to journalReview articlepeer-review

    2 Citations (Scopus)


    Numerous pharmacological approaches have failed to modify the high incidence of restenosis after balloon coronary angioplasty. This inability to alter the restenosis process was caused in part by our incomplete understanding of its pathology. Neointimal formation and geometric remodeling cause the restenosis after angioplasty. The development of restenosis involves vascular smooth muscle cells (VSMCs) migration and proliferation. Angiotensin II has been shown to stimulate the growth of VSMCs via an action on the angiotensin II AT1 receptor subtype. Angiotensin II AT1 receptor antagonists can block the angiotensin II-induced these actions. Angiotensin II AT1 receptor antagonists may block the restenosis after balloon coronary angioplasty.

    Original languageEnglish
    Pages (from-to)1158-1163
    Number of pages6
    JournalNippon rinsho. Japanese journal of clinical medicine
    Issue number5
    Publication statusPublished - May 1999

    All Science Journal Classification (ASJC) codes

    • Medicine(all)


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