Vasoacting Agents Flavone Acetic Acid and Hydralazine Given in Combination Enhance Antitumor Effects under Condition of Hyperthermia

Manabu Yamamoto, Tetsuya Kusumoto, Kazuya Endo, Hideo Baba, Yoshihisa Sakaguchi, Yoshihiko Maehara, Keizo Sugimachia

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

The combined effects of flavone acetic acid (FAA), hydralazine (HYD) and hyperthermia on B16 melanoma cells and solid tumor were examined in vitro and in vivo. In vitro, hyperthermia did not enhance the cytotoxicity of the combined use of FAA and HYD. In vivo, growth inhibition of B16 melanoma solid tumor by FAA (150 mg/kg) combined with HYD (5.0 mg/kg) could not be differentiated from that by FAA or HYD alone. Increased antitumor effect was recognized when FAA combined with HYD was used under conditions of hyperthermia. FAA combined with HYD significantly reduced tumor blood flow compared to FAA alone or HYD alone. We thus conclude that the significant reduction in tumor blood flow may play an important role in the enhanced antitumor effects of the combined treatment with FAA, HYD, and hyperthermia.

Original languageEnglish
Pages (from-to)147-152
Number of pages6
JournalOncology (Switzerland)
Volume53
Issue number2
DOIs
Publication statusPublished - Jan 1 1996

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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