Vasodilating effect of di-peptides in thoracic aortas from spontaneously hypertensive rats

Mitsuru Tanaka; Toshiro Matsui; Yusuke Ushida; Kiyoshi Matsumoto

doi:10.1271/bbb.60119

Vasodilating effect of di-peptides in thoracic aortas from spontaneously hypertensive rats

Mitsuru Tanaka, Toshiro Matsui, Yusuke Ushida, Kiyoshi Matsumoto

Food Science and Biotechnology

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

In this study, we found that antihypertensive di-peptide Val-Tyr (VY) showed a vascular relaxation effect in KCl-induced contraction of thoracic aorta rings from 18-week-old spontaneously hypertensive rats among di-peptides of VY, Ile-Tyr, and Tyr-Val irrespective of their angiotensin I-converting enzyme inhibitory activity. The effect was endothelium-independent, and was closely associated with vascular responses in the vascular smooth muscle layer.

Original language	English
Pages (from-to)	2292-2295
Number of pages	4
Journal	Bioscience, Biotechnology and Biochemistry
Volume	70
Issue number	9
DOIs	https://doi.org/10.1271/bbb.60119
Publication status	Published - 2006

All Science Journal Classification (ASJC) codes

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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title = "Vasodilating effect of di-peptides in thoracic aortas from spontaneously hypertensive rats",

abstract = "In this study, we found that antihypertensive di-peptide Val-Tyr (VY) showed a vascular relaxation effect in KCl-induced contraction of thoracic aorta rings from 18-week-old spontaneously hypertensive rats among di-peptides of VY, Ile-Tyr, and Tyr-Val irrespective of their angiotensin I-converting enzyme inhibitory activity. The effect was endothelium-independent, and was closely associated with vascular responses in the vascular smooth muscle layer.",

author = "Mitsuru Tanaka and Toshiro Matsui and Yusuke Ushida and Kiyoshi Matsumoto",

note = "Funding Information: This research was supported by a Grand-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan (no. 15380094).",

year = "2006",

doi = "10.1271/bbb.60119",

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T1 - Vasodilating effect of di-peptides in thoracic aortas from spontaneously hypertensive rats

AU - Tanaka, Mitsuru

AU - Matsui, Toshiro

AU - Ushida, Yusuke

AU - Matsumoto, Kiyoshi

N1 - Funding Information: This research was supported by a Grand-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan (no. 15380094).

PY - 2006

Y1 - 2006

N2 - In this study, we found that antihypertensive di-peptide Val-Tyr (VY) showed a vascular relaxation effect in KCl-induced contraction of thoracic aorta rings from 18-week-old spontaneously hypertensive rats among di-peptides of VY, Ile-Tyr, and Tyr-Val irrespective of their angiotensin I-converting enzyme inhibitory activity. The effect was endothelium-independent, and was closely associated with vascular responses in the vascular smooth muscle layer.

AB - In this study, we found that antihypertensive di-peptide Val-Tyr (VY) showed a vascular relaxation effect in KCl-induced contraction of thoracic aorta rings from 18-week-old spontaneously hypertensive rats among di-peptides of VY, Ile-Tyr, and Tyr-Val irrespective of their angiotensin I-converting enzyme inhibitory activity. The effect was endothelium-independent, and was closely associated with vascular responses in the vascular smooth muscle layer.

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DO - 10.1271/bbb.60119

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SN - 0916-8451

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EP - 2295

JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

IS - 9

ER -

Vasodilating effect of di-peptides in thoracic aortas from spontaneously hypertensive rats

Abstract

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