Vasodilating effect of di-peptides in thoracic aortas from spontaneously hypertensive rats

Mitsuru Tanaka, Toshiro Matsui, Yusuke Ushida, Kiyoshi Matsumoto

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

In this study, we found that antihypertensive di-peptide Val-Tyr (VY) showed a vascular relaxation effect in KCl-induced contraction of thoracic aorta rings from 18-week-old spontaneously hypertensive rats among di-peptides of VY, Ile-Tyr, and Tyr-Val irrespective of their angiotensin I-converting enzyme inhibitory activity. The effect was endothelium-independent, and was closely associated with vascular responses in the vascular smooth muscle layer.

Original languageEnglish
Pages (from-to)2292-2295
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume70
Issue number9
DOIs
Publication statusPublished - 2006

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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