Vasodilating effect of the new β-blocker tilisolol hydrochloride in humans

T. Imaizumi, A. Takeshita, N. Nakamura, Yoshitaka Hirooka, S. Suzuki, M. Yoshida, M. Nakamura

Research output: Contribution to journalArticle

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Abstract

The effects of a new β-blocker, (±)-4-(3-tert-butylamino-2-hydroxypropoxy)-2-methyl-1(2H)-isoquinoli none hydrochloride (tilisolol hydrochloride, N-696), on forearm circulation were examined and compared with those of propranolol in healthy young males. N-696 (30 mg/d for 7 days) decreased heart rate from 75 ± 4 to 56 ± 2 bpm (p < 0.01) and decreased mean blood pressure from 86 ± 2 to 79 ± 2 mmHg (p < 0.05) (n = 7). Propranolol (60 mg/d for 7 days) decreased heart rate from 62 ± 1 to 51 ± 2 (p < 0.01) and decreased mean blood pressure from 83 ± 3 to 73 ± 3 mmHg (p < 0.01) (n = 7). Resting forearm blood flow and forearm vascular resistance were not altered by N-696, whereas propranolol decreased forearm blood flow (p < 0.05) and increased forearm vascular resistance (p < 0.01). Reflex forearm vasoconstriction was examined by measuring forearm vascular resistance with a strain gauge plethysmograph during lower body negative pressure (LBNP). The regression line relating central venous pressure and forearm vascular resistance during LBNP was shifted toward the resistance axis by propranolol but was not altered by N-696. Propranolol augmented forearm vascular responses to intraarterially infused norepinephrine but N-696 did not alter them. Thus, in contrast to propranolol, N-696 lowered blood pressure and heart rate without peripheral vasoconstriction and did not augment forearm vasoconstrictive responses to norepinephrine.

Original languageEnglish
Pages (from-to)1342-1344
Number of pages3
JournalArzneimittel-Forschung/Drug Research
Volume38
Issue number9
Publication statusPublished - Jan 1 1988

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Forearm
Propranolol
Vascular Resistance
Lower Body Negative Pressure
Heart Rate
Blood Pressure
Vasoconstriction
Norepinephrine
tilisolol
Central Venous Pressure
Blood Vessels
Reflex

All Science Journal Classification (ASJC) codes

  • Drug Discovery

Cite this

Imaizumi, T., Takeshita, A., Nakamura, N., Hirooka, Y., Suzuki, S., Yoshida, M., & Nakamura, M. (1988). Vasodilating effect of the new β-blocker tilisolol hydrochloride in humans. Arzneimittel-Forschung/Drug Research, 38(9), 1342-1344.

Vasodilating effect of the new β-blocker tilisolol hydrochloride in humans. / Imaizumi, T.; Takeshita, A.; Nakamura, N.; Hirooka, Yoshitaka; Suzuki, S.; Yoshida, M.; Nakamura, M.

In: Arzneimittel-Forschung/Drug Research, Vol. 38, No. 9, 01.01.1988, p. 1342-1344.

Research output: Contribution to journalArticle

Imaizumi, T, Takeshita, A, Nakamura, N, Hirooka, Y, Suzuki, S, Yoshida, M & Nakamura, M 1988, 'Vasodilating effect of the new β-blocker tilisolol hydrochloride in humans', Arzneimittel-Forschung/Drug Research, vol. 38, no. 9, pp. 1342-1344.
Imaizumi T, Takeshita A, Nakamura N, Hirooka Y, Suzuki S, Yoshida M et al. Vasodilating effect of the new β-blocker tilisolol hydrochloride in humans. Arzneimittel-Forschung/Drug Research. 1988 Jan 1;38(9):1342-1344.
Imaizumi, T. ; Takeshita, A. ; Nakamura, N. ; Hirooka, Yoshitaka ; Suzuki, S. ; Yoshida, M. ; Nakamura, M. / Vasodilating effect of the new β-blocker tilisolol hydrochloride in humans. In: Arzneimittel-Forschung/Drug Research. 1988 ; Vol. 38, No. 9. pp. 1342-1344.
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