Vasodilatory effect of arginine vasopressin is mediated by nitric oxide in human forearm vessels

Tatsuya Tagawa, Tsutomu Imaizumi, Toyonari Endo, Masanari Shiramoto, Yoshitaka Hirooka, Shin Ichi Ando, Akira Takeshita

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    74 Citations (Scopus)

    Abstract

    Arginine vasopressin (AVP) causes biphasic changes in vascular resistance in human forearms; vasoconstriction at lower doses and vasodilation at higher doses. Vasoconstriction is mediated by the V1 receptor. However, the mechanism of A VP-induced vasodilation is not known. We investigated whether AVP-induced vasodilation is mediated by nitric oxide (NO) in human forearms by examining the effects of L-arginine (a precursor of NO) and NG-monomethyl-L-arginine (L-NMMA, a blocker of NO synthase) on AVP-induced vasodilation. AVP was infused intraarterially at doses of 0.05, 0.1, 0.2, 0.5, and 1.0 ng/kg per min (n = 8). The lower doses of AVP (≤ 0.1 ng/kg per min) increased, whereas the higher doses of AVP (≥ 0.5 ng/kg per min) decreased forearm vascular resistance (FVR) (P < 0.01). Intraarterially infused L-arginine at 10 mg/min did not alter arterial pressure, baseline FVR, or heart rate. L-arginine did not alter the magnitude of AVP-induced vasoconstriction at the lower doses, but L-arginine augmented the magnitude of AVP-induced vasodilation at doses of 0.2 (P < 0.05), 0.5 (P < 0.01), and 1.0 (P < 0.05) ng/kg per min. In another group (n = 6), intraarterially infused L-NMMA (4 μmol/min for 5 min) increased baseline FVR without systemic effects, and inhibited acetylcholine-induced vasodilation (P < 0.01). L-NMMA at this dose inhibited AVP-induced vasodilation (P < 0.01) but did not affect vasoconstriction. L-arginine reversed the inhibitory effect of L-NMMA. Our results suggest that the vasodilatory effect of AVP may be mediated by NO in human forearms.

    Original languageEnglish
    Pages (from-to)1483-1490
    Number of pages8
    JournalJournal of Clinical Investigation
    Volume92
    Issue number3
    DOIs
    Publication statusPublished - Sep 1993

    All Science Journal Classification (ASJC) codes

    • Medicine(all)

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