Vba2p, A vacuolar membrane protein involved in basic amino acid transport in schizosaccharomyces pombe

Naoko Sugimoto; Tomoko Iwaki; Soracom Chardwiriyapreecha; Masamitsu Shimazu; Takayuki Sekito; Kaoru Takegawa; Yoshimi Kakinuma

doi:10.1271/bbb.100627

Vba2p, A vacuolar membrane protein involved in basic amino acid transport in schizosaccharomyces pombe

Naoko Sugimoto, Tomoko Iwaki, Soracom Chardwiriyapreecha, Masamitsu Shimazu, Takayuki Sekito, Kaoru Takegawa, Yoshimi Kakinuma

Systems Biology

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

A recent study filling the gap in the genome sequence in the left arm of chromosome 2 of Schizosaccharomyces pombe revealed a homolog of budding yeast Vba2p, a vacuolar transporter of basic amino acids. GFP-tagged Vba2p in fission yeast was localized to the vacuolar membrane. Upon disruption of vba2, the uptake of several amino acids, including lysine, histidine, and arginine, was impaired. A transient increase in lysine uptake under nitrogen starvation was lowered by this mutation. These findings suggest that Vba2p is involved in basic amino acid transport in S. pombe under diverse conditions.

Original language	English
Pages (from-to)	2166-2169
Number of pages	4
Journal	Bioscience, Biotechnology and Biochemistry
Volume	74
Issue number	10
DOIs	https://doi.org/10.1271/bbb.100627
Publication status	Published - 2010

All Science Journal Classification (ASJC) codes

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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10.1271/bbb.100627

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Vba2p, A vacuolar membrane protein involved in basic amino acid transport in schizosaccharomyces pombe. / Sugimoto, Naoko; Iwaki, Tomoko; Chardwiriyapreecha, Soracom; Shimazu, Masamitsu; Sekito, Takayuki; Takegawa, Kaoru; Kakinuma, Yoshimi.

In: Bioscience, Biotechnology and Biochemistry, Vol. 74, No. 10, 2010, p. 2166-2169.

Research output: Contribution to journal › Article › peer-review

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