Vba2p, A vacuolar membrane protein involved in basic amino acid transport in schizosaccharomyces pombe

Naoko Sugimoto, Tomoko Iwaki, Soracom Chardwiriyapreecha, Masamitsu Shimazu, Takayuki Sekito, Kaoru Takegawa, Yoshimi Kakinuma

Research output: Contribution to journalArticle

2 Citations (Scopus)


A recent study filling the gap in the genome sequence in the left arm of chromosome 2 of Schizosaccharomyces pombe revealed a homolog of budding yeast Vba2p, a vacuolar transporter of basic amino acids. GFP-tagged Vba2p in fission yeast was localized to the vacuolar membrane. Upon disruption of vba2, the uptake of several amino acids, including lysine, histidine, and arginine, was impaired. A transient increase in lysine uptake under nitrogen starvation was lowered by this mutation. These findings suggest that Vba2p is involved in basic amino acid transport in S. pombe under diverse conditions.

Original languageEnglish
Pages (from-to)2166-2169
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Issue number10
Publication statusPublished - Nov 8 2010


All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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