Vba2p, A vacuolar membrane protein involved in basic amino acid transport in schizosaccharomyces pombe

Naoko Sugimoto, Tomoko Iwaki, Soracom Chardwiriyapreecha, Masamitsu Shimazu, Takayuki Sekito, Kaoru Takegawa, Yoshimi Kakinuma

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Abstract

A recent study filling the gap in the genome sequence in the left arm of chromosome 2 of Schizosaccharomyces pombe revealed a homolog of budding yeast Vba2p, a vacuolar transporter of basic amino acids. GFP-tagged Vba2p in fission yeast was localized to the vacuolar membrane. Upon disruption of vba2, the uptake of several amino acids, including lysine, histidine, and arginine, was impaired. A transient increase in lysine uptake under nitrogen starvation was lowered by this mutation. These findings suggest that Vba2p is involved in basic amino acid transport in S. pombe under diverse conditions.

Original languageEnglish
Pages (from-to)2166-2169
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume74
Issue number10
DOIs
Publication statusPublished - Nov 8 2010

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All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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