VEGF-C and VEGF-D expression is correlated with lymphatic vessel density and lymph node metastasis in oral squamous cell carcinoma: Implications for use as a prognostic marker

Tsuyoshi Sugiura, Yoshiko Inoue, Ryosuke Matsuki, kotaro ishii, Miho Takahashi, Masakazu Abe, Kanemitsu Shirasuna

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

The prognosis of patients with oral squamous cell carcinoma (SCC) is influenced by the presence of lymph node metastasis. In this study, we analyzed the relationship between lymphangiogenesis and the expression of VEGF-C and VEGF-D in association with lymph node metastasis in oral SCC. Oral SCC biopsy specimens (160 cases) were examined for lymphatic vessel density (LVD) and the expression of VEGF-C and VEGF-D immunohistochemically. The levels of VEGF-C and VEGF-D expression and LVD were significantly associated with lymph node metastasis (p<0.001). The expression of VEGF-C and VEGF-D increased the LVD significantly (p<0.001). Multivariate analysis showed that VEGF-C expression and LVD were significantly associated with lymph node metastasis (p<0.001). This study presents clinical evidence for the important roles of VEGF-C and VEGF-D in lymphangiogenesis and lymphatic metastasis of oral SCC, and suggests that VEGF-C or LVD can effectively predict lymphatic metastasis of oral SCC.

Original languageEnglish
Pages (from-to)673-680
Number of pages8
JournalInternational Journal of Oncology
Volume34
Issue number3
DOIs
Publication statusPublished - Apr 20 2009

Fingerprint

Vascular Endothelial Growth Factor D
Vascular Endothelial Growth Factor C
Lymphatic Vessels
Squamous Cell Carcinoma
Lymph Nodes
Neoplasm Metastasis
Lymphangiogenesis
Lymphatic Metastasis
Multivariate Analysis
Biopsy

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

VEGF-C and VEGF-D expression is correlated with lymphatic vessel density and lymph node metastasis in oral squamous cell carcinoma : Implications for use as a prognostic marker. / Sugiura, Tsuyoshi; Inoue, Yoshiko; Matsuki, Ryosuke; ishii, kotaro; Takahashi, Miho; Abe, Masakazu; Shirasuna, Kanemitsu.

In: International Journal of Oncology, Vol. 34, No. 3, 20.04.2009, p. 673-680.

Research output: Contribution to journalArticle

Sugiura, Tsuyoshi ; Inoue, Yoshiko ; Matsuki, Ryosuke ; ishii, kotaro ; Takahashi, Miho ; Abe, Masakazu ; Shirasuna, Kanemitsu. / VEGF-C and VEGF-D expression is correlated with lymphatic vessel density and lymph node metastasis in oral squamous cell carcinoma : Implications for use as a prognostic marker. In: International Journal of Oncology. 2009 ; Vol. 34, No. 3. pp. 673-680.
@article{e69827ee0dd24248a871d24fea685e30,
title = "VEGF-C and VEGF-D expression is correlated with lymphatic vessel density and lymph node metastasis in oral squamous cell carcinoma: Implications for use as a prognostic marker",
abstract = "The prognosis of patients with oral squamous cell carcinoma (SCC) is influenced by the presence of lymph node metastasis. In this study, we analyzed the relationship between lymphangiogenesis and the expression of VEGF-C and VEGF-D in association with lymph node metastasis in oral SCC. Oral SCC biopsy specimens (160 cases) were examined for lymphatic vessel density (LVD) and the expression of VEGF-C and VEGF-D immunohistochemically. The levels of VEGF-C and VEGF-D expression and LVD were significantly associated with lymph node metastasis (p<0.001). The expression of VEGF-C and VEGF-D increased the LVD significantly (p<0.001). Multivariate analysis showed that VEGF-C expression and LVD were significantly associated with lymph node metastasis (p<0.001). This study presents clinical evidence for the important roles of VEGF-C and VEGF-D in lymphangiogenesis and lymphatic metastasis of oral SCC, and suggests that VEGF-C or LVD can effectively predict lymphatic metastasis of oral SCC.",
author = "Tsuyoshi Sugiura and Yoshiko Inoue and Ryosuke Matsuki and kotaro ishii and Miho Takahashi and Masakazu Abe and Kanemitsu Shirasuna",
year = "2009",
month = "4",
day = "20",
doi = "10.3892/ijo_00000193",
language = "English",
volume = "34",
pages = "673--680",
journal = "International Journal of Oncology",
issn = "1019-6439",
publisher = "Spandidos Publications",
number = "3",

}

TY - JOUR

T1 - VEGF-C and VEGF-D expression is correlated with lymphatic vessel density and lymph node metastasis in oral squamous cell carcinoma

T2 - Implications for use as a prognostic marker

AU - Sugiura, Tsuyoshi

AU - Inoue, Yoshiko

AU - Matsuki, Ryosuke

AU - ishii, kotaro

AU - Takahashi, Miho

AU - Abe, Masakazu

AU - Shirasuna, Kanemitsu

PY - 2009/4/20

Y1 - 2009/4/20

N2 - The prognosis of patients with oral squamous cell carcinoma (SCC) is influenced by the presence of lymph node metastasis. In this study, we analyzed the relationship between lymphangiogenesis and the expression of VEGF-C and VEGF-D in association with lymph node metastasis in oral SCC. Oral SCC biopsy specimens (160 cases) were examined for lymphatic vessel density (LVD) and the expression of VEGF-C and VEGF-D immunohistochemically. The levels of VEGF-C and VEGF-D expression and LVD were significantly associated with lymph node metastasis (p<0.001). The expression of VEGF-C and VEGF-D increased the LVD significantly (p<0.001). Multivariate analysis showed that VEGF-C expression and LVD were significantly associated with lymph node metastasis (p<0.001). This study presents clinical evidence for the important roles of VEGF-C and VEGF-D in lymphangiogenesis and lymphatic metastasis of oral SCC, and suggests that VEGF-C or LVD can effectively predict lymphatic metastasis of oral SCC.

AB - The prognosis of patients with oral squamous cell carcinoma (SCC) is influenced by the presence of lymph node metastasis. In this study, we analyzed the relationship between lymphangiogenesis and the expression of VEGF-C and VEGF-D in association with lymph node metastasis in oral SCC. Oral SCC biopsy specimens (160 cases) were examined for lymphatic vessel density (LVD) and the expression of VEGF-C and VEGF-D immunohistochemically. The levels of VEGF-C and VEGF-D expression and LVD were significantly associated with lymph node metastasis (p<0.001). The expression of VEGF-C and VEGF-D increased the LVD significantly (p<0.001). Multivariate analysis showed that VEGF-C expression and LVD were significantly associated with lymph node metastasis (p<0.001). This study presents clinical evidence for the important roles of VEGF-C and VEGF-D in lymphangiogenesis and lymphatic metastasis of oral SCC, and suggests that VEGF-C or LVD can effectively predict lymphatic metastasis of oral SCC.

UR - http://www.scopus.com/inward/record.url?scp=64549103445&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=64549103445&partnerID=8YFLogxK

U2 - 10.3892/ijo_00000193

DO - 10.3892/ijo_00000193

M3 - Article

C2 - 19212672

AN - SCOPUS:64549103445

VL - 34

SP - 673

EP - 680

JO - International Journal of Oncology

JF - International Journal of Oncology

SN - 1019-6439

IS - 3

ER -