VEGFR2 is selectively expressed by FOXP3high CD4+ Treg

Hiroyuki Suzuki, Hideya Onishi, Junji Wada, Akio Yamasaki, Haruo Tanaka, Kenji Nakano, Takashi Morisaki, Mitsuo Katano

Research output: Contribution to journalArticlepeer-review

74 Citations (Scopus)

Abstract

CD25+ FOXP3+CD4+ T cells (Treg) have been considered to play an important role in immune tolerance against several tumor antigens. It has also been indicated that high-level expression of FOXP3 (FOXP3high) is sufficient to confer suppressive activity to normal non-Treg. Here, we showed for the first time that vascular endothelial growth factor receptor 2 (VEGFR2) is selectively expressed by FOXP3high but not FOXP3low Treg. Such VEGFR2+ Treg exist in several tissues including PBMC and malignant effusion-derived lymphocytes. In conclusion, VEGFR2 may be a novel target for controlling Treg with highly suppressive function.

Original languageEnglish
Pages (from-to)197-203
Number of pages7
JournalEuropean Journal of Immunology
Volume40
Issue number1
DOIs
Publication statusPublished - Jan 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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