Velocity gap theory developed for magnifying resolutions without changing separation mechanisms or separation lengths

Yong Zhang, Jun Wang, Yukihiro Okamoto, Manabu Tokeshi, Noritada Kaji, Yoshinobu Baba

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Separation techniques, such as chromatography and electrophoresis, form the basis in many fields and are continually developed for better separation efficiency. The efforts normally involve a new mechanism together with sufficient separation length. We develop a velocity gap theory to make things simple. The theory is based on the discovery that the velocity gap (VG) effect could enlarge the distance between two moving objects. Mathematical deduction certified that the resolution may be magnified infinitely without changing the separation mechanism or the separation length. DNA separation confirmed its practical feasibility by achieving 2-5 times higher resolution on a microchip. Our results indicate that VG effect could enlarge the distance between two moving objects and may potentially be utilized to ameliorate separation efficiency.

Original languageEnglish
Pages (from-to)2745-2750
Number of pages6
JournalAnalytical chemistry
Volume81
Issue number7
DOIs
Publication statusPublished - Apr 1 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry

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