Venodilator effects of adenosine triphosphate and sodium nitroprusside; Comparisons during controlled hypotension

Sumio Hoka, Akira Takeshita, Kazuko Aishima, Hideki Higashi, Shousuke Takahashi, Junichi Yoshitake

Research output: Contribution to journalArticle

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Abstract

Adenosine triphosphate as well as sodium nitroprusside has been used for hypotensive anesthesia. The purpose of this study was to examine the possibility that two hypotensive drugs may exert different effects on venous capacitance during controlled hypotension. In rats anesthetized with ketamine, mean arterial pressure was lowered to 50 mmHg by intravenous infusion of adenosine triphosphate or sodium nitroprusside. Venous capacitance was assessed before and during induced hypotension by measuring the mean circulatory filling pressure (MCFP). MCFP was measured after briefly arresting the circulation by inflating an indwelling balloon in the right atrium. MCFP was lower during adenosine triphosphate-induced as well as sodium nitroprusside-induced hypotension as compared with the respective value at control"(P<O.01 for adenosine triphosphate and sodium nitroprusside). However, the decrease in MCFP by adenosine triphosphate (0.8±0.1 mmHg) was less (P<O.Ol) than that by sodium nitroprusside (2.3±0.3 mmHg). These results suggest that at a comparable level of arterial hypotension venodilator effect of adenosine triphosphate was less than that of sodium nitroprusside. Less venodilatation during adenosine triphosphate-induced hypotension may contribute to the maintenance of cardiac output during hypotensive anesthesia.

Original languageEnglish
Pages (from-to)143-147
Number of pages5
JournalJournal of Anesthesia
Volume1
Issue number2
DOIs
Publication statusPublished - Sep 1 1987

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Controlled Hypotension
Nitroprusside
Adenosine Triphosphate
Pressure
Anesthesia
Ketamine
Heart Atria
Intravenous Infusions
Cardiac Output
Hypotension
Arterial Pressure
Maintenance

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

Cite this

Venodilator effects of adenosine triphosphate and sodium nitroprusside; Comparisons during controlled hypotension. / Hoka, Sumio; Takeshita, Akira; Aishima, Kazuko; Higashi, Hideki; Takahashi, Shousuke; Yoshitake, Junichi.

In: Journal of Anesthesia, Vol. 1, No. 2, 01.09.1987, p. 143-147.

Research output: Contribution to journalArticle

Hoka, S, Takeshita, A, Aishima, K, Higashi, H, Takahashi, S & Yoshitake, J 1987, 'Venodilator effects of adenosine triphosphate and sodium nitroprusside; Comparisons during controlled hypotension', Journal of Anesthesia, vol. 1, no. 2, pp. 143-147. https://doi.org/10.1007/s0054070010143
Hoka, Sumio ; Takeshita, Akira ; Aishima, Kazuko ; Higashi, Hideki ; Takahashi, Shousuke ; Yoshitake, Junichi. / Venodilator effects of adenosine triphosphate and sodium nitroprusside; Comparisons during controlled hypotension. In: Journal of Anesthesia. 1987 ; Vol. 1, No. 2. pp. 143-147.
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