Ventral abdominal wall dysmorphogenesis of Msx1/Msx2 double-mutant mice

Hidenao Ogi; Kentaro Suzuki; Yukiko Ogino; Mika Kamimura; Mami Miyado; Xu Ying; Zunyi Zhang; Masanori Shinohara; Yiping Chen; Gen Yamada

doi:10.1002/ar.a.20180

Ventral abdominal wall dysmorphogenesis of Msx1/Msx2 double-mutant mice

Hidenao Ogi, Kentaro Suzuki, Yukiko Ogino, Mika Kamimura, Mami Miyado, Xu Ying, Zunyi Zhang, Masanori Shinohara, Yiping Chen, Gen Yamada

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Msx1 and Msx2 genes encode the homeodomain transcription factors. Several gene knockout mice and expression studies suggest that they possess functionally redundant roles in embryogenesis. In this study, we revealed that Msx1 and Msx2 were expressed during ventral body wall formation in an overlapping manner. Msx1/Msx2 double-mutant mice displayed embryonic abdominal wall defects with disorganized muscle layers and connective tissues. These findings indicate that Msx1 and Msx2 play roles in concert during embryonic ventral abdominal wall formation.

Original language	English
Pages (from-to)	424-430
Number of pages	7
Journal	Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology
Volume	284
Issue number	1
DOIs	https://doi.org/10.1002/ar.a.20180
Publication status	Published - May 2005
Externally published	Yes

All Science Journal Classification (ASJC) codes

Anatomy
Agricultural and Biological Sciences (miscellaneous)

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abstract = "Msx1 and Msx2 genes encode the homeodomain transcription factors. Several gene knockout mice and expression studies suggest that they possess functionally redundant roles in embryogenesis. In this study, we revealed that Msx1 and Msx2 were expressed during ventral body wall formation in an overlapping manner. Msx1/Msx2 double-mutant mice displayed embryonic abdominal wall defects with disorganized muscle layers and connective tissues. These findings indicate that Msx1 and Msx2 play roles in concert during embryonic ventral abdominal wall formation.",

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AU - Ogi, Hidenao

AU - Suzuki, Kentaro

AU - Ogino, Yukiko

AU - Kamimura, Mika

AU - Miyado, Mami

AU - Ying, Xu

AU - Zhang, Zunyi

AU - Shinohara, Masanori

AU - Chen, Yiping

AU - Yamada, Gen

PY - 2005/5

Y1 - 2005/5

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AB - Msx1 and Msx2 genes encode the homeodomain transcription factors. Several gene knockout mice and expression studies suggest that they possess functionally redundant roles in embryogenesis. In this study, we revealed that Msx1 and Msx2 were expressed during ventral body wall formation in an overlapping manner. Msx1/Msx2 double-mutant mice displayed embryonic abdominal wall defects with disorganized muscle layers and connective tissues. These findings indicate that Msx1 and Msx2 play roles in concert during embryonic ventral abdominal wall formation.

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Ventral abdominal wall dysmorphogenesis of Msx1/Msx2 double-mutant mice

Abstract

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