Ventral abdominal wall dysmorphogenesis of Msx1/Msx2 double-mutant mice

Hidenao Ogi, Kentaro Suzuki, Yukiko Ogino, Mika Kamimura, Mami Miyado, Xu Ying, Zunyi Zhang, Masanori Shinohara, Yiping Chen, Gen Yamada

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


Msx1 and Msx2 genes encode the homeodomain transcription factors. Several gene knockout mice and expression studies suggest that they possess functionally redundant roles in embryogenesis. In this study, we revealed that Msx1 and Msx2 were expressed during ventral body wall formation in an overlapping manner. Msx1/Msx2 double-mutant mice displayed embryonic abdominal wall defects with disorganized muscle layers and connective tissues. These findings indicate that Msx1 and Msx2 play roles in concert during embryonic ventral abdominal wall formation.

Original languageEnglish
Pages (from-to)424-430
Number of pages7
JournalAnatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology
Issue number1
Publication statusPublished - May 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Agricultural and Biological Sciences (miscellaneous)


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