Currently available surrogate markers of osteoporosis including areal bone mineral density (aBMD) measured by dual energy absorptiometry (DXA), bone turnover markers (BTMs), and fracture risk assessment tool (FRAX®) are limited for the use as targets, because those values are not directly reflecting bone strength. Because directly measuring the strength of any bone in a living human subject is not feasible, the combination of finite element analysis (FEA) and clinical computed tomography (CT) is an alternative and powerful technique for noninvasive assessment of whole bone strength. While there are several limitations including the radiation exposure, FEA has the potential to improve clinical assessment of osteoporosis. In this chapter, methodology and recent advances of FEA in this field including treatment efficacy assessment and fracture risk assessment are presented.
|Title of host publication||Skeletal Adaptation to Mechanical Strain|
|Subtitle of host publication||A Key Role in Osteoporosis|
|Number of pages||19|
|Publication status||Published - Jan 1 2015|
All Science Journal Classification (ASJC) codes