Abstract
Aims: The aim of this study was to evaluate very long-term clinical outcomes and potential predictors after percutaneous coronary intervention (PCI) with bare metal stents (BMS) for unprotected left main coronary artery disease (ULMCAD). Methods and results: From March 1991 to August 2001, 151 patients who underwent PCI with BMS for ULMCAD were investigated retrospectively. The patient-oriented major adverse cardiac events (MACE) were defined as the occurrence of all-cause death, any MI, and any coronary revascularisation. The median follow-up duration was 10.5 years. The mean age was 69.9±11.5 years, and 106 patients (70.2%) were male. At 10 years, the incidences of cardiac death (CD), target lesion revascularisation (TLR) and patient-oriented MACE were 11.1%, 25.2% and 81.9%, respectively. In multivariate analysis, the pre-reference diameter of the left main trunk (LMT) was significantly associated with TLR (adjusted hazard ratio [HR] [95% confidence interval (CI)], 0.28 [0.14-0.54], p<0.001) and the SYNTAX score remained an independent predictor of patient-oriented MACE (adjusted HR [95% CI], 1.03 [1.007-1.05], p=0.009). Conclusions: The pre-reference diameter of LMT was significantly associated with TLR, and the SYNTAX score significantly predicted the risk of patient-oriented MACE at 10 years. BMS implantation for larger size of ULMCAD with a lower SYNTAX score was feasible for up to 10 years.
| Original language | English |
|---|---|
| Pages (from-to) | 962-969 |
| Number of pages | 8 |
| Journal | EuroIntervention |
| Volume | 8 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Dec 1 2012 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine
Cite this
Very long-term outcomes after percutaneous coronary intervention with bare metal stents for unprotected left main coronary artery disease. / Nomura, Akihiro; Yamaji, Kyohei; Shirai, Shinichi; Omata, Fumio; Soga, Yoshimitsu; Nagashima, Michio; Arita, Takeshi; Ando, Kenji; Sakai, Koyu; Goya, Masahiko; Yokoi, Hiroyoshi; Iwabuchi, Masashi; Nobuyoshi, Masakiyo.
In: EuroIntervention, Vol. 8, No. 8, 01.12.2012, p. 962-969.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Very long-term outcomes after percutaneous coronary intervention with bare metal stents for unprotected left main coronary artery disease
AU - Nomura, Akihiro
AU - Yamaji, Kyohei
AU - Shirai, Shinichi
AU - Omata, Fumio
AU - Soga, Yoshimitsu
AU - Nagashima, Michio
AU - Arita, Takeshi
AU - Ando, Kenji
AU - Sakai, Koyu
AU - Goya, Masahiko
AU - Yokoi, Hiroyoshi
AU - Iwabuchi, Masashi
AU - Nobuyoshi, Masakiyo
PY - 2012/12/1
Y1 - 2012/12/1
N2 - Aims: The aim of this study was to evaluate very long-term clinical outcomes and potential predictors after percutaneous coronary intervention (PCI) with bare metal stents (BMS) for unprotected left main coronary artery disease (ULMCAD). Methods and results: From March 1991 to August 2001, 151 patients who underwent PCI with BMS for ULMCAD were investigated retrospectively. The patient-oriented major adverse cardiac events (MACE) were defined as the occurrence of all-cause death, any MI, and any coronary revascularisation. The median follow-up duration was 10.5 years. The mean age was 69.9±11.5 years, and 106 patients (70.2%) were male. At 10 years, the incidences of cardiac death (CD), target lesion revascularisation (TLR) and patient-oriented MACE were 11.1%, 25.2% and 81.9%, respectively. In multivariate analysis, the pre-reference diameter of the left main trunk (LMT) was significantly associated with TLR (adjusted hazard ratio [HR] [95% confidence interval (CI)], 0.28 [0.14-0.54], p<0.001) and the SYNTAX score remained an independent predictor of patient-oriented MACE (adjusted HR [95% CI], 1.03 [1.007-1.05], p=0.009). Conclusions: The pre-reference diameter of LMT was significantly associated with TLR, and the SYNTAX score significantly predicted the risk of patient-oriented MACE at 10 years. BMS implantation for larger size of ULMCAD with a lower SYNTAX score was feasible for up to 10 years.
AB - Aims: The aim of this study was to evaluate very long-term clinical outcomes and potential predictors after percutaneous coronary intervention (PCI) with bare metal stents (BMS) for unprotected left main coronary artery disease (ULMCAD). Methods and results: From March 1991 to August 2001, 151 patients who underwent PCI with BMS for ULMCAD were investigated retrospectively. The patient-oriented major adverse cardiac events (MACE) were defined as the occurrence of all-cause death, any MI, and any coronary revascularisation. The median follow-up duration was 10.5 years. The mean age was 69.9±11.5 years, and 106 patients (70.2%) were male. At 10 years, the incidences of cardiac death (CD), target lesion revascularisation (TLR) and patient-oriented MACE were 11.1%, 25.2% and 81.9%, respectively. In multivariate analysis, the pre-reference diameter of the left main trunk (LMT) was significantly associated with TLR (adjusted hazard ratio [HR] [95% confidence interval (CI)], 0.28 [0.14-0.54], p<0.001) and the SYNTAX score remained an independent predictor of patient-oriented MACE (adjusted HR [95% CI], 1.03 [1.007-1.05], p=0.009). Conclusions: The pre-reference diameter of LMT was significantly associated with TLR, and the SYNTAX score significantly predicted the risk of patient-oriented MACE at 10 years. BMS implantation for larger size of ULMCAD with a lower SYNTAX score was feasible for up to 10 years.
UR - http://www.scopus.com/inward/record.url?scp=84872125583&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84872125583&partnerID=8YFLogxK
U2 - 10.4244/EIJV8I8A146
DO - 10.4244/EIJV8I8A146
M3 - Article
C2 - 23014985
AN - SCOPUS:84872125583
VL - 8
SP - 962
EP - 969
JO - EuroIntervention
JF - EuroIntervention
SN - 1774-024X
IS - 8
ER -