Vesicle-mediated protein transport pathways to the vacuole in Schizosaccharomyces pombe

Kaoru Takegawa, Tomoko Iwaki, Yasuko Fujita, Tomotake Morita, Akira Hosomi, Naotaka Tanaka

Research output: Contribution to journalReview article

38 Citations (Scopus)

Abstract

The vacuole of Saccharomyces cerevisiae plays essential roles not only for osmoregulation and ion homeostasis but also down-regulation (degradation) of cell surface proteins and protein and organellar turnover. Genetic selections and genome-wide screens in S. cerevisiae have resulted in the identification of a large number of genes required for delivery of proteins to the vacuole. Although the complete genome sequence of the fission yeast Schizosaccharomyces pombe has been reported, there have been few reports on the proteins required for vacuolar protein transport and vacuolar biogenesis in S. pombe. Recent progress in the S. pombe genome project of has revealed that most of the genes required for vacuolar biogenesis and protein transport are conserved between S. pombe and S. cerevisiae. This suggests that the basic machinery of vesicle-mediated protein delivery to the vacuole is conserved between the two yeasts. Identification and characterization of the fission yeast counterparts of the budding yeast Vps and Vps-related proteins have facilitated our understanding of protein transport pathways to the vacuole in S. pombe. This review focuses on the recent advances in vesicle-mediated protein transport to the vacuole in S. pombe.

Original languageEnglish
Pages (from-to)399-417
Number of pages19
JournalCell structure and function
Volume28
Issue number5
DOIs
Publication statusPublished - Oct 1 2003

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Schizosaccharomyces
Protein Transport
Vacuoles
Saccharomyces cerevisiae
Genome
Proteins
Osmoregulation
Saccharomycetales
Genetic Selection
Genes
Membrane Proteins
Homeostasis
Down-Regulation
Yeasts
Ions

All Science Journal Classification (ASJC) codes

  • Physiology
  • Molecular Biology
  • Cell Biology

Cite this

Vesicle-mediated protein transport pathways to the vacuole in Schizosaccharomyces pombe. / Takegawa, Kaoru; Iwaki, Tomoko; Fujita, Yasuko; Morita, Tomotake; Hosomi, Akira; Tanaka, Naotaka.

In: Cell structure and function, Vol. 28, No. 5, 01.10.2003, p. 399-417.

Research output: Contribution to journalReview article

Takegawa, Kaoru ; Iwaki, Tomoko ; Fujita, Yasuko ; Morita, Tomotake ; Hosomi, Akira ; Tanaka, Naotaka. / Vesicle-mediated protein transport pathways to the vacuole in Schizosaccharomyces pombe. In: Cell structure and function. 2003 ; Vol. 28, No. 5. pp. 399-417.
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