Vessel Formation by Choroidal Endothelial Cells In Vitro Is Modulated by Retinal Pigment Epithelial Cells

Taiji Sakamoto, Hitomi Sakamoto, Todd L. Murphy, Christine Spee, Danilo Soriano, Tatsuro Ishibashi, David R. Hinton, Stephen J. Ryan

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Overlying RPE cells stimulate the formation of tubelike structures by choroidal endothelial cells more effectively than do fibroblasts or pericytes but inhibit BCE tube formation in older cultures. The effect involves endothelial proliferation and differentiation. The stimulatory effect of overlying RPE cells can be inhibited by neutralizing antibodies to vascular endothelial growth factor and basic fibroblast growth factor, which suggests that these growth factors play an important role in this phenomenon.

Original languageEnglish
Pages (from-to)512-520
Number of pages9
JournalArchives of Ophthalmology
Volume113
Issue number4
DOIs
Publication statusPublished - Jan 1 1995

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Retinal Pigments
Endothelial Cells
Epithelial Cells
Pericytes
Fibroblast Growth Factor 2
Neutralizing Antibodies
Vascular Endothelial Growth Factor A
Intercellular Signaling Peptides and Proteins
Fibroblasts
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Vessel Formation by Choroidal Endothelial Cells In Vitro Is Modulated by Retinal Pigment Epithelial Cells. / Sakamoto, Taiji; Sakamoto, Hitomi; Murphy, Todd L.; Spee, Christine; Soriano, Danilo; Ishibashi, Tatsuro; Hinton, David R.; Ryan, Stephen J.

In: Archives of Ophthalmology, Vol. 113, No. 4, 01.01.1995, p. 512-520.

Research output: Contribution to journalArticle

Sakamoto, Taiji ; Sakamoto, Hitomi ; Murphy, Todd L. ; Spee, Christine ; Soriano, Danilo ; Ishibashi, Tatsuro ; Hinton, David R. ; Ryan, Stephen J. / Vessel Formation by Choroidal Endothelial Cells In Vitro Is Modulated by Retinal Pigment Epithelial Cells. In: Archives of Ophthalmology. 1995 ; Vol. 113, No. 4. pp. 512-520.
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