Vessel Formation by Choroidal Endothelial Cells In Vitro Is Modulated by Retinal Pigment Epithelial Cells

Taiji Sakamoto, Hitomi Sakamoto, Todd L. Murphy, Christine Spee, Danilo Soriano, Tatsuro Ishibashi, David R. Hinton, Stephen J. Ryan

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Abstract

Overlying RPE cells stimulate the formation of tubelike structures by choroidal endothelial cells more effectively than do fibroblasts or pericytes but inhibit BCE tube formation in older cultures. The effect involves endothelial proliferation and differentiation. The stimulatory effect of overlying RPE cells can be inhibited by neutralizing antibodies to vascular endothelial growth factor and basic fibroblast growth factor, which suggests that these growth factors play an important role in this phenomenon.

Original languageEnglish
Pages (from-to)512-520
Number of pages9
JournalArchives of Ophthalmology
Volume113
Issue number4
DOIs
Publication statusPublished - Apr 1995

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All Science Journal Classification (ASJC) codes

  • Ophthalmology

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