TY - JOUR
T1 - Viral diversity limits immune diversity in asymptomatic phase of HIV infection
AU - Iwami, Shingo
AU - Nakaoka, Shinji
AU - Takeuchi, Yasuhiro
N1 - Funding Information:
The first author is supported by Research Fellowships of the Japan Society for the Promotion of Science for Young Scientists. The second author’s work was partly supported by the Sasakawa Scientific Research Grant from The Japan Science Society.
PY - 2008/5
Y1 - 2008/5
N2 - We propose a new diversity threshold theory which states that the specific CTLs to the viral strain become inactivated (that is, some HIV strain can escape from its specific immune response) when the diversity of HIV strains exceeds some threshold number. We call this number "immune diversity threshold". Our theory can explain the inactivation of specific immune response and a limit of maximum immune diversity. We can conclude that the accumulation of viral diversity eventually leads to AIDS.
AB - We propose a new diversity threshold theory which states that the specific CTLs to the viral strain become inactivated (that is, some HIV strain can escape from its specific immune response) when the diversity of HIV strains exceeds some threshold number. We call this number "immune diversity threshold". Our theory can explain the inactivation of specific immune response and a limit of maximum immune diversity. We can conclude that the accumulation of viral diversity eventually leads to AIDS.
UR - http://www.scopus.com/inward/record.url?scp=41149114474&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=41149114474&partnerID=8YFLogxK
U2 - 10.1016/j.tpb.2008.01.003
DO - 10.1016/j.tpb.2008.01.003
M3 - Article
C2 - 18342352
AN - SCOPUS:41149114474
SN - 0040-5809
VL - 73
SP - 332
EP - 341
JO - Theoretical Population Biology
JF - Theoretical Population Biology
IS - 3
ER -
