Viral diversity limits immune diversity in asymptomatic phase of HIV infection

Shingo Iwami, Shinji Nakaoka, Yasuhiro Takeuchi

Research output: Contribution to journalArticle

12 Citations (Scopus)


We propose a new diversity threshold theory which states that the specific CTLs to the viral strain become inactivated (that is, some HIV strain can escape from its specific immune response) when the diversity of HIV strains exceeds some threshold number. We call this number "immune diversity threshold". Our theory can explain the inactivation of specific immune response and a limit of maximum immune diversity. We can conclude that the accumulation of viral diversity eventually leads to AIDS.

Original languageEnglish
Pages (from-to)332-341
Number of pages10
JournalTheoretical Population Biology
Issue number3
Publication statusPublished - May 1 2008
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences(all)
  • Ecology, Evolution, Behavior and Systematics

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