Vitamin B 12 derivatives as activators of soluble guanylyl cyclase

Keith Ó Proinsias, Daniel T. Gryko, Yoshio Hisaeda, Emil Martin, Jonathan L. Sessler, Dorota Gryko

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Various newly prepared and previously known vitamin B 12 derivatives have been studied as potential soluble guanylyl cyclase (sGC) activators. All compounds tested were found to activate the sGC enzyme, although to differing extents. The best results were obtained with the derivatives synthesized from c-lactone and possessing aliphatic amides in the c- and d-positions.

Original languageEnglish
Pages (from-to)8943-8947
Number of pages5
JournalJournal of Medicinal Chemistry
Volume55
Issue number20
DOIs
Publication statusPublished - Oct 25 2012

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Vitamin B 12
Lactones
Amides
Enzymes
Soluble Guanylyl Cyclase

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery

Cite this

Ó Proinsias, K., Gryko, D. T., Hisaeda, Y., Martin, E., Sessler, J. L., & Gryko, D. (2012). Vitamin B 12 derivatives as activators of soluble guanylyl cyclase. Journal of Medicinal Chemistry, 55(20), 8943-8947. https://doi.org/10.1021/jm3006959

Vitamin B 12 derivatives as activators of soluble guanylyl cyclase. / Ó Proinsias, Keith; Gryko, Daniel T.; Hisaeda, Yoshio; Martin, Emil; Sessler, Jonathan L.; Gryko, Dorota.

In: Journal of Medicinal Chemistry, Vol. 55, No. 20, 25.10.2012, p. 8943-8947.

Research output: Contribution to journalArticle

Ó Proinsias, K, Gryko, DT, Hisaeda, Y, Martin, E, Sessler, JL & Gryko, D 2012, 'Vitamin B 12 derivatives as activators of soluble guanylyl cyclase', Journal of Medicinal Chemistry, vol. 55, no. 20, pp. 8943-8947. https://doi.org/10.1021/jm3006959
Ó Proinsias, Keith ; Gryko, Daniel T. ; Hisaeda, Yoshio ; Martin, Emil ; Sessler, Jonathan L. ; Gryko, Dorota. / Vitamin B 12 derivatives as activators of soluble guanylyl cyclase. In: Journal of Medicinal Chemistry. 2012 ; Vol. 55, No. 20. pp. 8943-8947.
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