Vitamin D3 analogues improve cafe au lait spots in patients with von Recklinghausen's disease: Experimental and clinical studies

Juichiro Nakayama, Hiromaro Kiryu, Kazunori Urabe, Shinjiro Matsuo, Satoko Shibata, Tetsuya Koga, Masutaka Furue

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Topical application of vitamin D3 analogues for 6 months was found to be effective in improving the pigmentation of cafe au lait spots in patients with yon Recklinghausen's disease. Treatment of q au lait spots grafted onto nude mice with a vitamin D3 analogue caused suppression of bromodeoxyuridine uptake in the cells of the basal layer. Vitamin D3 analogues also decreased melanin pigment in cafe au lait spots after 4 weeks of treatment. Thus, it is considered that long-term application of vitamin D3 analogues is effective both for improving the pigmentation of cafe au lait spots and suppressing the development of neurofibromas in patients with von Recklinghausen's disease.

Original languageEnglish
Pages (from-to)202-206
Number of pages5
JournalEuropean Journal of Dermatology
Volume9
Issue number3
Publication statusPublished - Jan 1 1999

All Science Journal Classification (ASJC) codes

  • Dermatology

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