Vitamin e administration erases an enhanced oxidation in multiple sclerosis

Jing Zhi Guan, Wei Ping Guan, Toyoki Maeda

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Systemic peroxidation status has been reported as a pathogenic factor for multiple sclerosis (MS). Systemically elevated oxidation levels are associated with serum lipid peroxidation and somatic telomere length (TL) shortening. We investigated whether vitamin E (VE) administration suppresses peroxidation and improves clinical symptoms in 34 MS patients. We analyzed serum lipid peroxidation and degree of TL in circulating leukocytes of MS patients before and after VE treatment. The oxidation level was enhanced and TL was shortened in MS. The MS population treated with VE 400 mg/day for 3 months showed significantly reduced serum lipid oxidation level with maintenance of TL. These findings showed that systemic peroxidation is associated with the development of MS. Antioxidants such as vitamin E can be candidates for supplementary therapeutic agents for MS.

Original languageEnglish
Pages (from-to)1181-1183
Number of pages3
JournalCanadian journal of physiology and pharmacology
Volume96
Issue number11
DOIs
Publication statusPublished - Jan 1 2018

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Vitamins
Multiple Sclerosis
Vitamin E
Telomere
Lipid Peroxidation
Serum
Telomere Homeostasis
Telomere Shortening
Leukocytes
Antioxidants
Lipids
Therapeutics
Population

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology
  • Physiology (medical)

Cite this

Vitamin e administration erases an enhanced oxidation in multiple sclerosis. / Guan, Jing Zhi; Guan, Wei Ping; Maeda, Toyoki.

In: Canadian journal of physiology and pharmacology, Vol. 96, No. 11, 01.01.2018, p. 1181-1183.

Research output: Contribution to journalArticle

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