Vitamin E Enhances Prostacyclin Production by Cultured Aortic Endothelial Cells

Fumio Umeda, Makoto Kunisaki, Toyoshi Inoguchi, Hajime Nawata

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The effect of vitamin E on prostacyclin (PGI2) production by cultured bovine aortic endothelial cells was evaluated in vitro. We found that human plasma-derived serum (PDS) conveys a stimulatory effect on PGI2 production by cultured vascular endothelial cells. In the present study, therefore, PDS was used as a physiological stimulant for PGI2 production. There was no effect of vitamin E alone on PGI2 production without stimulation by PDS. However, simultaneous addition of vitamin E and PDS to the cultures enhanced PGI2 production in a dose-dependent manner. Furthermore, preincubation with vitamin E prior to stimulation with PDS also enhanced PGI2 production. The enhancing effect of preincubation with vitamin E was demonstrated to occur in a time- and dose-dependent manner. These results clearly indicate that vitamin E at physiological doses can enhance PGI2 production by cultured bovine aortic endothelial cells stimulated with an agent such as PDS. It seems likely that vitamin E may contribute to increase PGI2 synthesis by the vascular wall in vivo, thereby reducing platelet aggregation and thrombus formation.

Original languageEnglish
Pages (from-to)175-183
Number of pages9
JournalJournal of Clinical Biochemistry and Nutrition
Volume8
Issue number3
DOIs
Publication statusPublished - Jan 1 1990

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Clinical Biochemistry

Fingerprint Dive into the research topics of 'Vitamin E Enhances Prostacyclin Production by Cultured Aortic Endothelial Cells'. Together they form a unique fingerprint.

  • Cite this