Vitamin E isoforms α-tocotrienol and γ-tocopherol prevent cerebral infarction in mice

Kenichi Mishima, Takamitsu Tanaka, Fengling Pu, Nobuaki Egashira, Katsunori Iwasaki, Ryoji Hidaka, Kazuhisa Matsunaga, Jiro Takata, Yoshiharu Karube, Michihiro Fujiwara

Research output: Contribution to journalArticle

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Abstract

α-tocopherol and its derivatives have been shown to be effective in reducing cerebral ischemia-induced brain damage. However, the effects of other vitamin E isoforms have not been characterized. In the present study, we investigated the effects of six different isoforms of vitamin E on the ischemic brain damage in the mice middle cerebral artery (MCA) occlusion model. All vitamin E isoforms were injected i.v., twice, immediately before and 3 h after the occlusion. α-tocopherol (2 mM), α-tocotrienol (0.2 and 2 mM) and γ-tocopherol (0.2 and 2 mM) significantly decreased the size of the cerebral infarcts 1 day after the MCA occlusion, while γ-tocotrienol, δ-tocopherol and δ-tocotrienol showed no effect on the cerebral infarcts. These results suggest that α-tocotrienol and γ-tocopherol are potent and effective agents for preventing cerebral infarction induced by MCA occlusion.

Original languageEnglish
Pages (from-to)56-60
Number of pages5
JournalNeuroscience Letters
Volume337
Issue number1
DOIs
Publication statusPublished - Jan 30 2003
Externally publishedYes

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Tocotrienols
Tocopherols
Cerebral Infarction
Vitamin E
Protein Isoforms
Middle Cerebral Artery Infarction
Brain
Brain Ischemia

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Vitamin E isoforms α-tocotrienol and γ-tocopherol prevent cerebral infarction in mice. / Mishima, Kenichi; Tanaka, Takamitsu; Pu, Fengling; Egashira, Nobuaki; Iwasaki, Katsunori; Hidaka, Ryoji; Matsunaga, Kazuhisa; Takata, Jiro; Karube, Yoshiharu; Fujiwara, Michihiro.

In: Neuroscience Letters, Vol. 337, No. 1, 30.01.2003, p. 56-60.

Research output: Contribution to journalArticle

Mishima, K, Tanaka, T, Pu, F, Egashira, N, Iwasaki, K, Hidaka, R, Matsunaga, K, Takata, J, Karube, Y & Fujiwara, M 2003, 'Vitamin E isoforms α-tocotrienol and γ-tocopherol prevent cerebral infarction in mice', Neuroscience Letters, vol. 337, no. 1, pp. 56-60. https://doi.org/10.1016/S0304-3940(02)01293-4
Mishima, Kenichi ; Tanaka, Takamitsu ; Pu, Fengling ; Egashira, Nobuaki ; Iwasaki, Katsunori ; Hidaka, Ryoji ; Matsunaga, Kazuhisa ; Takata, Jiro ; Karube, Yoshiharu ; Fujiwara, Michihiro. / Vitamin E isoforms α-tocotrienol and γ-tocopherol prevent cerebral infarction in mice. In: Neuroscience Letters. 2003 ; Vol. 337, No. 1. pp. 56-60.
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AU - Hidaka, Ryoji

AU - Matsunaga, Kazuhisa

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