TY - JOUR
T1 - Vitamin E isoforms α-tocotrienol and γ-tocopherol prevent cerebral infarction in mice
AU - Mishima, Kenichi
AU - Tanaka, Takamitsu
AU - Pu, Fengling
AU - Egashira, Nobuaki
AU - Iwasaki, Katsunori
AU - Hidaka, Ryoji
AU - Matsunaga, Kazuhisa
AU - Takata, Jiro
AU - Karube, Yoshiharu
AU - Fujiwara, Michihiro
N1 - Funding Information:
This study was supported in part by a Grant-in Aid for Scientific Research (No.14572171) from the Ministry of Education, Science and Culture of Japan, and by the Advanced Materials Institute of Fukuoka University and by a grant (No. 991001) from the Central Research Institute of Fukuoka University. We thank Miss Y. Shimoda and Miss R. Matsutani for their excellent technical assistance.
PY - 2003/1/30
Y1 - 2003/1/30
N2 - α-tocopherol and its derivatives have been shown to be effective in reducing cerebral ischemia-induced brain damage. However, the effects of other vitamin E isoforms have not been characterized. In the present study, we investigated the effects of six different isoforms of vitamin E on the ischemic brain damage in the mice middle cerebral artery (MCA) occlusion model. All vitamin E isoforms were injected i.v., twice, immediately before and 3 h after the occlusion. α-tocopherol (2 mM), α-tocotrienol (0.2 and 2 mM) and γ-tocopherol (0.2 and 2 mM) significantly decreased the size of the cerebral infarcts 1 day after the MCA occlusion, while γ-tocotrienol, δ-tocopherol and δ-tocotrienol showed no effect on the cerebral infarcts. These results suggest that α-tocotrienol and γ-tocopherol are potent and effective agents for preventing cerebral infarction induced by MCA occlusion.
AB - α-tocopherol and its derivatives have been shown to be effective in reducing cerebral ischemia-induced brain damage. However, the effects of other vitamin E isoforms have not been characterized. In the present study, we investigated the effects of six different isoforms of vitamin E on the ischemic brain damage in the mice middle cerebral artery (MCA) occlusion model. All vitamin E isoforms were injected i.v., twice, immediately before and 3 h after the occlusion. α-tocopherol (2 mM), α-tocotrienol (0.2 and 2 mM) and γ-tocopherol (0.2 and 2 mM) significantly decreased the size of the cerebral infarcts 1 day after the MCA occlusion, while γ-tocotrienol, δ-tocopherol and δ-tocotrienol showed no effect on the cerebral infarcts. These results suggest that α-tocotrienol and γ-tocopherol are potent and effective agents for preventing cerebral infarction induced by MCA occlusion.
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U2 - 10.1016/S0304-3940(02)01293-4
DO - 10.1016/S0304-3940(02)01293-4
M3 - Article
C2 - 12524170
AN - SCOPUS:0037472341
SN - 0304-3940
VL - 337
SP - 56
EP - 60
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1
ER -