Vitellogenin receptor mutation leads to the oogenesis mutant phenotype "scanty vitellin" of the silkworm, bombyx mori

Ying Lin, Yan Meng, Yan Xia Wang, Juan Luo, Susumu Katsuma, Cong Wen Yang, Yutaka Banno, Takahiro Kusakabe, Toru Shimada, Qing You Xia

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Background: The vitellogenin receptor (VgR) mediates the uptake of vitellogenin (Vg) from the hemolymph by developing oocytes. Results: VgR with the mutational EGF1 domain can bind ligand proteins but cannot be dissociated under acidic conditions. The mutant is lethal in embryos. Conclusion: Bombyx mori VgR (BmVgR) has an important role in egg formation and embryonic development. Significance: BmVgR is a potential target for pest control.

Original languageEnglish
Pages (from-to)13345-13355
Number of pages11
JournalJournal of Biological Chemistry
Volume288
Issue number19
DOIs
Publication statusPublished - May 10 2013

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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