Volume study on the micelle formation of local anesthetic dibucaine hydrochloride and dodecyltrimethylammonium chloride mixtures

Michio Yamanaka, H. Matsuki, S. Kaneshina

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Densities of aqueous solutions of mixtures of dibucaine hydrochloride (DCHC), a local anesthetic, and dodecyltrimethylammonium chloride (DTAC) were measured as functions of total molality. The apparent molar volumes of the mixtures were calculated from the density data. The molar volumes in the monomeric and micellar states were evaluated from the dependence of the apparent molar volume on the total molality. The critical micelle concentration (cmc) of the mixtures was determined from the break point of the apparent molar volume vs. the total molality curves, while the micellar composition was evaluated from the dependence of the cmc on the mole fraction of DTAC in the mixture. The composition diagram of micellization has a swollen cigar shape, slightly distorted in the composition range near the DTAC component; such a distortion indicates slightly non-ideal mixing between the hydrophobic groups of DCHC and DTAC molecules in the micelle. However, the molar volume of micellar state varies depending upon the micellar composition along a straight line connecting the molar volumes of DCHC and DTAC. Moreover, the volume of micelle formation is smaller for DCHC, which has larger monomer and micellar volumes than DTAC, and increases linearly with increasing DTAC composition in the micelle. Therefore, the bulky structure of the hydrophobic part of the DCHC molecule affects both the miscibility and the volume behavior in the DCHC-DTAC mixed micelles.

Original languageEnglish
Pages (from-to)2159-2164
Number of pages6
JournalBulletin of the Chemical Society of Japan
Volume68
Issue number8
DOIs
Publication statusPublished - Aug 1995

Fingerprint

Dibucaine
Micelles
Local Anesthetics
Density (specific gravity)
Chemical analysis
Critical micelle concentration
Micellization
Molecules
dodecyltrimethylammonium
Tobacco Products
Solubility
Monomers

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

Volume study on the micelle formation of local anesthetic dibucaine hydrochloride and dodecyltrimethylammonium chloride mixtures. / Yamanaka, Michio; Matsuki, H.; Kaneshina, S.

In: Bulletin of the Chemical Society of Japan, Vol. 68, No. 8, 08.1995, p. 2159-2164.

Research output: Contribution to journalArticle

@article{d024d3d5886b49e297e53348d579930b,
title = "Volume study on the micelle formation of local anesthetic dibucaine hydrochloride and dodecyltrimethylammonium chloride mixtures",
abstract = "Densities of aqueous solutions of mixtures of dibucaine hydrochloride (DCHC), a local anesthetic, and dodecyltrimethylammonium chloride (DTAC) were measured as functions of total molality. The apparent molar volumes of the mixtures were calculated from the density data. The molar volumes in the monomeric and micellar states were evaluated from the dependence of the apparent molar volume on the total molality. The critical micelle concentration (cmc) of the mixtures was determined from the break point of the apparent molar volume vs. the total molality curves, while the micellar composition was evaluated from the dependence of the cmc on the mole fraction of DTAC in the mixture. The composition diagram of micellization has a swollen cigar shape, slightly distorted in the composition range near the DTAC component; such a distortion indicates slightly non-ideal mixing between the hydrophobic groups of DCHC and DTAC molecules in the micelle. However, the molar volume of micellar state varies depending upon the micellar composition along a straight line connecting the molar volumes of DCHC and DTAC. Moreover, the volume of micelle formation is smaller for DCHC, which has larger monomer and micellar volumes than DTAC, and increases linearly with increasing DTAC composition in the micelle. Therefore, the bulky structure of the hydrophobic part of the DCHC molecule affects both the miscibility and the volume behavior in the DCHC-DTAC mixed micelles.",
author = "Michio Yamanaka and H. Matsuki and S. Kaneshina",
year = "1995",
month = "8",
doi = "10.1246/bcsj.68.2159",
language = "English",
volume = "68",
pages = "2159--2164",
journal = "Bulletin of the Chemical Society of Japan",
issn = "0009-2673",
publisher = "The Chemical Society of Japan",
number = "8",

}

TY - JOUR

T1 - Volume study on the micelle formation of local anesthetic dibucaine hydrochloride and dodecyltrimethylammonium chloride mixtures

AU - Yamanaka, Michio

AU - Matsuki, H.

AU - Kaneshina, S.

PY - 1995/8

Y1 - 1995/8

N2 - Densities of aqueous solutions of mixtures of dibucaine hydrochloride (DCHC), a local anesthetic, and dodecyltrimethylammonium chloride (DTAC) were measured as functions of total molality. The apparent molar volumes of the mixtures were calculated from the density data. The molar volumes in the monomeric and micellar states were evaluated from the dependence of the apparent molar volume on the total molality. The critical micelle concentration (cmc) of the mixtures was determined from the break point of the apparent molar volume vs. the total molality curves, while the micellar composition was evaluated from the dependence of the cmc on the mole fraction of DTAC in the mixture. The composition diagram of micellization has a swollen cigar shape, slightly distorted in the composition range near the DTAC component; such a distortion indicates slightly non-ideal mixing between the hydrophobic groups of DCHC and DTAC molecules in the micelle. However, the molar volume of micellar state varies depending upon the micellar composition along a straight line connecting the molar volumes of DCHC and DTAC. Moreover, the volume of micelle formation is smaller for DCHC, which has larger monomer and micellar volumes than DTAC, and increases linearly with increasing DTAC composition in the micelle. Therefore, the bulky structure of the hydrophobic part of the DCHC molecule affects both the miscibility and the volume behavior in the DCHC-DTAC mixed micelles.

AB - Densities of aqueous solutions of mixtures of dibucaine hydrochloride (DCHC), a local anesthetic, and dodecyltrimethylammonium chloride (DTAC) were measured as functions of total molality. The apparent molar volumes of the mixtures were calculated from the density data. The molar volumes in the monomeric and micellar states were evaluated from the dependence of the apparent molar volume on the total molality. The critical micelle concentration (cmc) of the mixtures was determined from the break point of the apparent molar volume vs. the total molality curves, while the micellar composition was evaluated from the dependence of the cmc on the mole fraction of DTAC in the mixture. The composition diagram of micellization has a swollen cigar shape, slightly distorted in the composition range near the DTAC component; such a distortion indicates slightly non-ideal mixing between the hydrophobic groups of DCHC and DTAC molecules in the micelle. However, the molar volume of micellar state varies depending upon the micellar composition along a straight line connecting the molar volumes of DCHC and DTAC. Moreover, the volume of micelle formation is smaller for DCHC, which has larger monomer and micellar volumes than DTAC, and increases linearly with increasing DTAC composition in the micelle. Therefore, the bulky structure of the hydrophobic part of the DCHC molecule affects both the miscibility and the volume behavior in the DCHC-DTAC mixed micelles.

UR - http://www.scopus.com/inward/record.url?scp=0029088248&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029088248&partnerID=8YFLogxK

U2 - 10.1246/bcsj.68.2159

DO - 10.1246/bcsj.68.2159

M3 - Article

AN - SCOPUS:0029088248

VL - 68

SP - 2159

EP - 2164

JO - Bulletin of the Chemical Society of Japan

JF - Bulletin of the Chemical Society of Japan

SN - 0009-2673

IS - 8

ER -