WAF1 genotype and endometrial cancer susceptibility

Toshiro Hachiya, Yumiko Kuriaki, Yousuke Ueoka, Jun I.Chi Nishida, Kiyoko Kato, Norio Wake

Research output: Contribution to journalArticle

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Abstract

The WAF1 protein, which is a downstream mediator of p53, functions as a universal inhibitor of cyclin-dependent kinases. The functional link between p53 and WAF1 suggests the possibility that alteration in WAF1 function constitutes an alternative mechanism to p53 inactivation. However, there are few reports describing somatic mutations of the WAF1 gene in various human malignancies. A polymorphism in the WAF1 gene, a C-to-A transversion at codon 31 resulting in the change of a serine (Ser) to an arginine (Arg), is well known. We found this substitution in 42 of 54 endometrial carcinoma patients. Allele frequency was 0.44/0.56 for the codon 31 polymorphism (Ser/Arg), the difference of allele frequency between patients and normal controls being significant (0.59/0.41 in normal controls). In addition, individuals carrying the codon 31 Arg allele had a tendency to develop histologically high-grade (odds ratio, 6.11) and clinically advanced tumors. We investigated the association of the Arg allele with the known risk factors of endometrial carcinomas. Statistical analyses of 42 cases and 32 controls carrying the codon 31 Arg allele identified hypertension (odds ratio, 4.33) and family history of cancer (odds ratio, 2.81) as positive risk factors. This implies that these two parameters may be associated with a tendency to develop endometrial carcinomas in individuals carrying the codon 31 Arg allele of the WAF1 gene.

Original languageEnglish
Pages (from-to)187-192
Number of pages6
JournalGynecologic Oncology
Volume72
Issue number2
DOIs
Publication statusPublished - Jan 1 1999

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Endometrial Neoplasms
Arginine
Codon
Genotype
Alleles
Odds Ratio
Gene Frequency
Serine
Genes
Neoplasms
Cyclin-Dependent Kinases
Hypertension
Mutation
Proteins

All Science Journal Classification (ASJC) codes

  • Oncology
  • Obstetrics and Gynaecology

Cite this

Hachiya, T., Kuriaki, Y., Ueoka, Y., Nishida, J. I. C., Kato, K., & Wake, N. (1999). WAF1 genotype and endometrial cancer susceptibility. Gynecologic Oncology, 72(2), 187-192. https://doi.org/10.1006/gyno.1998.5247

WAF1 genotype and endometrial cancer susceptibility. / Hachiya, Toshiro; Kuriaki, Yumiko; Ueoka, Yousuke; Nishida, Jun I.Chi; Kato, Kiyoko; Wake, Norio.

In: Gynecologic Oncology, Vol. 72, No. 2, 01.01.1999, p. 187-192.

Research output: Contribution to journalArticle

Hachiya, T, Kuriaki, Y, Ueoka, Y, Nishida, JIC, Kato, K & Wake, N 1999, 'WAF1 genotype and endometrial cancer susceptibility', Gynecologic Oncology, vol. 72, no. 2, pp. 187-192. https://doi.org/10.1006/gyno.1998.5247
Hachiya T, Kuriaki Y, Ueoka Y, Nishida JIC, Kato K, Wake N. WAF1 genotype and endometrial cancer susceptibility. Gynecologic Oncology. 1999 Jan 1;72(2):187-192. https://doi.org/10.1006/gyno.1998.5247
Hachiya, Toshiro ; Kuriaki, Yumiko ; Ueoka, Yousuke ; Nishida, Jun I.Chi ; Kato, Kiyoko ; Wake, Norio. / WAF1 genotype and endometrial cancer susceptibility. In: Gynecologic Oncology. 1999 ; Vol. 72, No. 2. pp. 187-192.
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