TY - JOUR
T1 - Waist circumference, body mass index and glycated hemoglobin in Japanese men and women
AU - Yoshida, Daigo
AU - Toyomura, Kengo
AU - Fukumoto, Jin
AU - Ueda, Naoyuki
AU - Ohnaka, Keizo
AU - Adachi, Masahiro
AU - Takayanagi, Ryoichi
AU - Kono, Suminori
N1 - Funding Information:
This study was supported by a grant for the 21st Century Center of Excellence (COE) Program (Kyushu University) from the Ministry of Education, Culture, Sports, Science and Technology, Japan.
PY - 2009/1
Y1 - 2009/1
N2 - Aims: To investigate the relationship of waist circumference and body mass index (BMI) with glycated hemoglobin (HbA1c) concentrations and to define optimal cutoffs for these indices with respect to elevated HbA1c (>5.8%). Methods: Study subjects were 7731 Japanese men and women aged 50-74 years in Fukuoka City who participated in the baseline survey of a cohort study on lifestyle-related diseases. Linear regression analysis and logistic regression analysis were used with and without adjustment for age, smoking, alcohol use and physical activity. Receiver operating characteristic (ROC) curve analysis was performed to determine optimal cutoffs for the obesity indices. Results: Waist circumference and BMI were linearly related to HbA1c concentrations in men and women with almost the same magnitude in strength. With adjustment for the covariates, mean percent changes of HbA1c per one standard deviation (S.D.) of waist circumference and BMI were 1.6% and 1.8% respectively in men, and 1.3% and 1.4% respectively in women. Adjusted odds ratios of elevated HbA1c per one S.D. of waist circumference and BMI also showed statistically significant increases. Optimal cutoffs for waist circumference were 89 cm for men and 85 cm for women. The area under the ROC curve was much greater in women than in men. Conclusions: In a population of middle-aged or elderly Japanese men and women, both waist circumference and BMI were strongly, positively associated with HbA1c concentrations. The determined optimal cutoff points for waist circumference did not support the current Japanese criterion for abdominal adiposity.
AB - Aims: To investigate the relationship of waist circumference and body mass index (BMI) with glycated hemoglobin (HbA1c) concentrations and to define optimal cutoffs for these indices with respect to elevated HbA1c (>5.8%). Methods: Study subjects were 7731 Japanese men and women aged 50-74 years in Fukuoka City who participated in the baseline survey of a cohort study on lifestyle-related diseases. Linear regression analysis and logistic regression analysis were used with and without adjustment for age, smoking, alcohol use and physical activity. Receiver operating characteristic (ROC) curve analysis was performed to determine optimal cutoffs for the obesity indices. Results: Waist circumference and BMI were linearly related to HbA1c concentrations in men and women with almost the same magnitude in strength. With adjustment for the covariates, mean percent changes of HbA1c per one standard deviation (S.D.) of waist circumference and BMI were 1.6% and 1.8% respectively in men, and 1.3% and 1.4% respectively in women. Adjusted odds ratios of elevated HbA1c per one S.D. of waist circumference and BMI also showed statistically significant increases. Optimal cutoffs for waist circumference were 89 cm for men and 85 cm for women. The area under the ROC curve was much greater in women than in men. Conclusions: In a population of middle-aged or elderly Japanese men and women, both waist circumference and BMI were strongly, positively associated with HbA1c concentrations. The determined optimal cutoff points for waist circumference did not support the current Japanese criterion for abdominal adiposity.
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U2 - 10.1016/j.dsx.2008.10.002
DO - 10.1016/j.dsx.2008.10.002
M3 - Article
AN - SCOPUS:62649131088
SN - 1871-4021
VL - 3
SP - 7
EP - 11
JO - Diabetes and Metabolic Syndrome: Clinical Research and Reviews
JF - Diabetes and Metabolic Syndrome: Clinical Research and Reviews
IS - 1
ER -
