Wall-eyed bilateral internuclear ophthalmoplegia (WEBINO) syndrome in a patient with neuromyelitis optica spectrum disorder and anti-aquaporin-4 antibody

Koji Shinoda, Takuya Matsushita, Konosuke Furuta, Noriko Isobe, Tomomi Yonekawa, Yasumasa Ohyagi, Jun Ichi Kira

Research output: Contribution to journalLetter

12 Citations (Scopus)

Abstract

This report describes, for the first time, an occurrence of wall-eyed bilateral internuclear ophthalmoplegia (WEBINO) in a 19-year-old female with neuromyelitis optica (NMO) spectrum disorder, who had anti-aquaporin-4 (AQP4) antibody. A high signal intensity lesion on T2-weighted MRI was detected in the midbrain tegmentum adjacent to the aqueduct, and presumably involved the medial longitudinal fasciculus bilaterally at the caudal levels. Plasma exchange resolved both WEBINO syndrome and the midbrain lesion. Although WEBINO syndrome is occasionally reported in multiple sclerosis patients, diagnosis of NMO should not be excluded in patients with WEBINO syndrome, because AQP4 is expressed abundantly around the periaqueductal region.

Original languageEnglish
Pages (from-to)885-887
Number of pages3
JournalMultiple Sclerosis Journal
Volume17
Issue number7
DOIs
Publication statusPublished - Jul 2011

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Aquaporin 4
Neuromyelitis Optica
Ocular Motility Disorders
Antibodies
Tegmentum Mesencephali
Plasma Exchange
Mesencephalon
Multiple Sclerosis

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Wall-eyed bilateral internuclear ophthalmoplegia (WEBINO) syndrome in a patient with neuromyelitis optica spectrum disorder and anti-aquaporin-4 antibody. / Shinoda, Koji; Matsushita, Takuya; Furuta, Konosuke; Isobe, Noriko; Yonekawa, Tomomi; Ohyagi, Yasumasa; Kira, Jun Ichi.

In: Multiple Sclerosis Journal, Vol. 17, No. 7, 07.2011, p. 885-887.

Research output: Contribution to journalLetter

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abstract = "This report describes, for the first time, an occurrence of wall-eyed bilateral internuclear ophthalmoplegia (WEBINO) in a 19-year-old female with neuromyelitis optica (NMO) spectrum disorder, who had anti-aquaporin-4 (AQP4) antibody. A high signal intensity lesion on T2-weighted MRI was detected in the midbrain tegmentum adjacent to the aqueduct, and presumably involved the medial longitudinal fasciculus bilaterally at the caudal levels. Plasma exchange resolved both WEBINO syndrome and the midbrain lesion. Although WEBINO syndrome is occasionally reported in multiple sclerosis patients, diagnosis of NMO should not be excluded in patients with WEBINO syndrome, because AQP4 is expressed abundantly around the periaqueductal region.",
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AU - Kira, Jun Ichi

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