Wash-free detection of C-reactive protein based on third-harmonic signal measurement of magnetic markers

Keiji Enpuku, Misako Shibakura, Yujiro Arao, Takako Mizoguchi, Akihiko Kandori, Misato Hara, Keiji Tsukada

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Abstract

We demonstrate wash-free detection of C-reactive proteins (CRPs) based on third-harmonic signal measurement of magnetic markers. In the method presented here, the CRP concentration can be detected from the decrease in the third-harmonic signal from the sample solution. The relationship between the detected signal and the CRP concentration can be modeled quantitatively using a logistic function. The quantities of CRP that were detected using the proposed method showed good correlation with those obtained using the conventional optical method with a washing process. We also demonstrate CRP detection in a hemolysis sample solution that is not optically transparent.

Original languageEnglish
Article number090309
JournalJapanese Journal of Applied Physics
Volume57
Issue number9
DOIs
Publication statusPublished - Sep 2018

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All Science Journal Classification (ASJC) codes

  • Engineering(all)
  • Physics and Astronomy(all)

Cite this

Enpuku, K., Shibakura, M., Arao, Y., Mizoguchi, T., Kandori, A., Hara, M., & Tsukada, K. (2018). Wash-free detection of C-reactive protein based on third-harmonic signal measurement of magnetic markers. Japanese Journal of Applied Physics, 57(9), [090309]. https://doi.org/10.7567/JJAP.57.090309