Water-proton relaxivities of DNA oligomers carrying TEMPO radicals

Yuichiro Sato, Hiroyuki Hayashi, Manami Okazaki, Mariko Aso, Satoru Karasawa, Shoji Ueki, Hiroshi Suemune, Noboru Koga

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15 Citations (Scopus)

Abstract

5-Uridine derivative carrying a TEMPO radical (UST) was prepared and its single strand (ssUST) and a double strand (dsUST) with its complementary strand were obtained. Similarly, single strands carrying two and five radicals (ssUST2 and ssUST5, respectively) and the corresponding doubles trands (dsUST2 and dsUST5) were prepared. Their electron paramagnetic resonance (EPR) spectra showed typical anisotropic broadening in the high field line. The rotational correlation times, τR, estimated by analyzing the EPR spectra are 1.1 × 10-10, 5.9 × 10-10, and 14 × 10-10 s for UST, ssUSTm, and dsUSTm, respectively. The water-proton relaxivities, r1 and r2, at 25 MHz, 0.59 T, and 25°C, also increased in the same order and the r1 values were 0.26, 0.41, and 0.56 mM-1 s-1 for UST, ssUSTm, and dsUSTm, respectively. The r1 values of 1.00 and 2.06 mM-1 s -1 for dsUST2 and dsUST5, respectively, were obtained.

Original languageEnglish
Pages (from-to)1055-1058
Number of pages4
JournalMagnetic Resonance in Chemistry
Volume46
Issue number11
DOIs
Publication statusPublished - Nov 1 2008

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Materials Science(all)

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