Water-Proton Relaxivities of Radical Nanoparticles Self-Assembled via Hydration or Dehydration Processes

Kosuke Morishita, Yuna Okamoto, Shuhei Murayama, Kazuteru Usui, Eriko Ohashi, Go Hirai, Ichio Aoki, Satoru Karasawa

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Nanoparticles capable of accumulating in tumor tissues are promising materials for tumor imaging and therapy. In this study, two radical nanoparticles (RNPs), denoted as 1 and 2, composed of self-assembled ureabenzene derivatives possessing one or two amphiphilic side chains were demonstrated to be candidates for metal-free functional magnetic resonance imaging (MRI) contrast agents (CAs). Because of the self-assembly behavior of 1 and 2 in a saline solution, spherical RNPs of sizes ∼50-90 and ∼30-100 nm were detected. In a highly concentrated solution, RNP 1 showed considerably small water-proton relaxivity values (r1 and r2), whereas RNP 2 showed an r1 value that was around 5 times larger than that of RNP 1. These distinct r1 values might be caused by differences in the self-assembly behavior by a hydration or dehydration process. In vivo studies with RNP 2 demonstrated a slightly enhanced T1-weighted image in mice, suggesting that the RNPs can potentially be used as metal-free functional MRI CAs for T1-weighted imaging.

Original languageEnglish
Pages (from-to)7810-7817
Number of pages8
JournalLangmuir
Volume33
Issue number31
DOIs
Publication statusPublished - Aug 8 2017

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

Fingerprint Dive into the research topics of 'Water-Proton Relaxivities of Radical Nanoparticles Self-Assembled via Hydration or Dehydration Processes'. Together they form a unique fingerprint.

  • Cite this

    Morishita, K., Okamoto, Y., Murayama, S., Usui, K., Ohashi, E., Hirai, G., Aoki, I., & Karasawa, S. (2017). Water-Proton Relaxivities of Radical Nanoparticles Self-Assembled via Hydration or Dehydration Processes. Langmuir, 33(31), 7810-7817. https://doi.org/10.1021/acs.langmuir.7b01126