Water-Proton Relaxivities of Radical Nanoparticles Self-Assembled via Hydration or Dehydration Processes

Kosuke Morishita, Yuna Okamoto, Shuhei Murayama, Kazuteru Usui, Eriko Ohashi, Go Hirai, Ichio Aoki, Satoru Karasawa

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Nanoparticles capable of accumulating in tumor tissues are promising materials for tumor imaging and therapy. In this study, two radical nanoparticles (RNPs), denoted as 1 and 2, composed of self-assembled ureabenzene derivatives possessing one or two amphiphilic side chains were demonstrated to be candidates for metal-free functional magnetic resonance imaging (MRI) contrast agents (CAs). Because of the self-assembly behavior of 1 and 2 in a saline solution, spherical RNPs of sizes ∼50-90 and ∼30-100 nm were detected. In a highly concentrated solution, RNP 1 showed considerably small water-proton relaxivity values (r1 and r2), whereas RNP 2 showed an r1 value that was around 5 times larger than that of RNP 1. These distinct r1 values might be caused by differences in the self-assembly behavior by a hydration or dehydration process. In vivo studies with RNP 2 demonstrated a slightly enhanced T1-weighted image in mice, suggesting that the RNPs can potentially be used as metal-free functional MRI CAs for T1-weighted imaging.

Original languageEnglish
Pages (from-to)7810-7817
Number of pages8
JournalLangmuir
Volume33
Issue number31
DOIs
Publication statusPublished - Aug 8 2017

Fingerprint

Dehydration
dehydration
Hydration
hydration
Protons
Nanoparticles
nanoparticles
protons
Water
water
Self assembly
Contrast Media
magnetic resonance
self assembly
Tumors
tumors
Metals
Imaging techniques
Sodium Chloride
metals

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

Cite this

Morishita, K., Okamoto, Y., Murayama, S., Usui, K., Ohashi, E., Hirai, G., ... Karasawa, S. (2017). Water-Proton Relaxivities of Radical Nanoparticles Self-Assembled via Hydration or Dehydration Processes. Langmuir, 33(31), 7810-7817. https://doi.org/10.1021/acs.langmuir.7b01126

Water-Proton Relaxivities of Radical Nanoparticles Self-Assembled via Hydration or Dehydration Processes. / Morishita, Kosuke; Okamoto, Yuna; Murayama, Shuhei; Usui, Kazuteru; Ohashi, Eriko; Hirai, Go; Aoki, Ichio; Karasawa, Satoru.

In: Langmuir, Vol. 33, No. 31, 08.08.2017, p. 7810-7817.

Research output: Contribution to journalArticle

Morishita, K, Okamoto, Y, Murayama, S, Usui, K, Ohashi, E, Hirai, G, Aoki, I & Karasawa, S 2017, 'Water-Proton Relaxivities of Radical Nanoparticles Self-Assembled via Hydration or Dehydration Processes', Langmuir, vol. 33, no. 31, pp. 7810-7817. https://doi.org/10.1021/acs.langmuir.7b01126
Morishita, Kosuke ; Okamoto, Yuna ; Murayama, Shuhei ; Usui, Kazuteru ; Ohashi, Eriko ; Hirai, Go ; Aoki, Ichio ; Karasawa, Satoru. / Water-Proton Relaxivities of Radical Nanoparticles Self-Assembled via Hydration or Dehydration Processes. In: Langmuir. 2017 ; Vol. 33, No. 31. pp. 7810-7817.
@article{313481a4b4204280b9422e7119715a56,
title = "Water-Proton Relaxivities of Radical Nanoparticles Self-Assembled via Hydration or Dehydration Processes",
abstract = "Nanoparticles capable of accumulating in tumor tissues are promising materials for tumor imaging and therapy. In this study, two radical nanoparticles (RNPs), denoted as 1 and 2, composed of self-assembled ureabenzene derivatives possessing one or two amphiphilic side chains were demonstrated to be candidates for metal-free functional magnetic resonance imaging (MRI) contrast agents (CAs). Because of the self-assembly behavior of 1 and 2 in a saline solution, spherical RNPs of sizes ∼50-90 and ∼30-100 nm were detected. In a highly concentrated solution, RNP 1 showed considerably small water-proton relaxivity values (r1 and r2), whereas RNP 2 showed an r1 value that was around 5 times larger than that of RNP 1. These distinct r1 values might be caused by differences in the self-assembly behavior by a hydration or dehydration process. In vivo studies with RNP 2 demonstrated a slightly enhanced T1-weighted image in mice, suggesting that the RNPs can potentially be used as metal-free functional MRI CAs for T1-weighted imaging.",
author = "Kosuke Morishita and Yuna Okamoto and Shuhei Murayama and Kazuteru Usui and Eriko Ohashi and Go Hirai and Ichio Aoki and Satoru Karasawa",
year = "2017",
month = "8",
day = "8",
doi = "10.1021/acs.langmuir.7b01126",
language = "English",
volume = "33",
pages = "7810--7817",
journal = "Langmuir",
issn = "0743-7463",
publisher = "American Chemical Society",
number = "31",

}

TY - JOUR

T1 - Water-Proton Relaxivities of Radical Nanoparticles Self-Assembled via Hydration or Dehydration Processes

AU - Morishita, Kosuke

AU - Okamoto, Yuna

AU - Murayama, Shuhei

AU - Usui, Kazuteru

AU - Ohashi, Eriko

AU - Hirai, Go

AU - Aoki, Ichio

AU - Karasawa, Satoru

PY - 2017/8/8

Y1 - 2017/8/8

N2 - Nanoparticles capable of accumulating in tumor tissues are promising materials for tumor imaging and therapy. In this study, two radical nanoparticles (RNPs), denoted as 1 and 2, composed of self-assembled ureabenzene derivatives possessing one or two amphiphilic side chains were demonstrated to be candidates for metal-free functional magnetic resonance imaging (MRI) contrast agents (CAs). Because of the self-assembly behavior of 1 and 2 in a saline solution, spherical RNPs of sizes ∼50-90 and ∼30-100 nm were detected. In a highly concentrated solution, RNP 1 showed considerably small water-proton relaxivity values (r1 and r2), whereas RNP 2 showed an r1 value that was around 5 times larger than that of RNP 1. These distinct r1 values might be caused by differences in the self-assembly behavior by a hydration or dehydration process. In vivo studies with RNP 2 demonstrated a slightly enhanced T1-weighted image in mice, suggesting that the RNPs can potentially be used as metal-free functional MRI CAs for T1-weighted imaging.

AB - Nanoparticles capable of accumulating in tumor tissues are promising materials for tumor imaging and therapy. In this study, two radical nanoparticles (RNPs), denoted as 1 and 2, composed of self-assembled ureabenzene derivatives possessing one or two amphiphilic side chains were demonstrated to be candidates for metal-free functional magnetic resonance imaging (MRI) contrast agents (CAs). Because of the self-assembly behavior of 1 and 2 in a saline solution, spherical RNPs of sizes ∼50-90 and ∼30-100 nm were detected. In a highly concentrated solution, RNP 1 showed considerably small water-proton relaxivity values (r1 and r2), whereas RNP 2 showed an r1 value that was around 5 times larger than that of RNP 1. These distinct r1 values might be caused by differences in the self-assembly behavior by a hydration or dehydration process. In vivo studies with RNP 2 demonstrated a slightly enhanced T1-weighted image in mice, suggesting that the RNPs can potentially be used as metal-free functional MRI CAs for T1-weighted imaging.

UR - http://www.scopus.com/inward/record.url?scp=85027020230&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85027020230&partnerID=8YFLogxK

U2 - 10.1021/acs.langmuir.7b01126

DO - 10.1021/acs.langmuir.7b01126

M3 - Article

AN - SCOPUS:85027020230

VL - 33

SP - 7810

EP - 7817

JO - Langmuir

JF - Langmuir

SN - 0743-7463

IS - 31

ER -