Water-soluble porphyrinoids as G-quadruplex binders and telomerase inhibitors

Yoshiya Ikawa, Sho Katsumata, Ryuichi Sakashita, Shinobu Sato, Shigeori Takenaka, Hiroyuki Furuta

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)

    Abstract

    Water-soluble derivatives of three kinds of expanded porphyrins (N-fused pentaphyrin, hexaphyrin, and heptaphyrin) were synthesized and their binding ability to G-quadruplex (G4-) DNA and the inhibitory effects on enzymatic telomere extension were investigated. While expanded porphyrins increased the melting temperature of G4-DNA more effectively than the regular porphyrins, a porphyrin isomer (N-confused porphyrin) showed the highest inhibitory effect on telomerase activity.

    Original languageEnglish
    Pages (from-to)1041-1048
    Number of pages8
    JournalJournal of Porphyrins and Phthalocyanines
    Volume20
    Issue number8-11
    DOIs
    Publication statusPublished - Aug 1 2016

    All Science Journal Classification (ASJC) codes

    • Chemistry(all)

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