Water-soluble porphyrinoids as G-quadruplex binders and telomerase inhibitors

Yoshiya Ikawa, Sho Katsumata, Ryuichi Sakashita, Shinobu Sato, Shigeori Takenaka, Hiroyuki Furuta

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Water-soluble derivatives of three kinds of expanded porphyrins (N-fused pentaphyrin, hexaphyrin, and heptaphyrin) were synthesized and their binding ability to G-quadruplex (G4-) DNA and the inhibitory effects on enzymatic telomere extension were investigated. While expanded porphyrins increased the melting temperature of G4-DNA more effectively than the regular porphyrins, a porphyrin isomer (N-confused porphyrin) showed the highest inhibitory effect on telomerase activity.

Original languageEnglish
Pages (from-to)1041-1048
Number of pages8
JournalJournal of Porphyrins and Phthalocyanines
Volume20
Issue number8-11
DOIs
Publication statusPublished - Aug 1 2016

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All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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