WECHE: A novel hematopoietic regulatory factor

Osamu Ohneda, Kinuko Ohneda, Hisayuki Nomiyama, Zhong Zheng, Steven A. Gold, Fumio Arai, Takeshi Miyamoto, Bruce E. Taillon, Richard A. McIndoe, Richard A. Shimkets, David A. Lewin, Toshio Suda, Laurence A. Lasky

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Previously, we described AGM-derived endothelial cell lines that either inhibited or permitted the development of erythroid or B cells. We utilized a differential gene expression method to isolate a chemokine, termed WECHE, from one of these cell lines. WECHE inhibited the formation of erythroid cells but had no effect on either myeloid or B cell formation. WECHE repressed BFU-E development from either mouse fetal liver or bone marrow progenitor cells but had no effect on colony formation induced by IL-3 or IL- 7. WECHE reduced HPP-CFC production from fetal liver-derived stem cells. WECHE hindered the growth of yolk sac-derived endothelial cells. WECHE was also chemotactic for bone marrow cells. Thus, WECHE is a novel chemokine that regulates hematopoietic differentiation.

Original languageEnglish
Pages (from-to)141-150
Number of pages10
JournalImmunity
Volume12
Issue number2
Publication statusPublished - Jan 1 2000
Externally publishedYes

Fingerprint

Erythroid Cells
Chemokines
Bone Marrow Cells
B-Lymphocytes
Stem Cells
Endothelial Cells
Cell Line
Interleukin-7
Yolk Sac
Erythroid Precursor Cells
Interleukin-3
Liver
Myeloid Cells
Gene Expression
Growth
N-(4'-fluorobutyrophenone)-4-(4-chlorophenyl)pyridinium

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Ohneda, O., Ohneda, K., Nomiyama, H., Zheng, Z., Gold, S. A., Arai, F., ... Lasky, L. A. (2000). WECHE: A novel hematopoietic regulatory factor. Immunity, 12(2), 141-150.

WECHE : A novel hematopoietic regulatory factor. / Ohneda, Osamu; Ohneda, Kinuko; Nomiyama, Hisayuki; Zheng, Zhong; Gold, Steven A.; Arai, Fumio; Miyamoto, Takeshi; Taillon, Bruce E.; McIndoe, Richard A.; Shimkets, Richard A.; Lewin, David A.; Suda, Toshio; Lasky, Laurence A.

In: Immunity, Vol. 12, No. 2, 01.01.2000, p. 141-150.

Research output: Contribution to journalArticle

Ohneda, O, Ohneda, K, Nomiyama, H, Zheng, Z, Gold, SA, Arai, F, Miyamoto, T, Taillon, BE, McIndoe, RA, Shimkets, RA, Lewin, DA, Suda, T & Lasky, LA 2000, 'WECHE: A novel hematopoietic regulatory factor', Immunity, vol. 12, no. 2, pp. 141-150.
Ohneda O, Ohneda K, Nomiyama H, Zheng Z, Gold SA, Arai F et al. WECHE: A novel hematopoietic regulatory factor. Immunity. 2000 Jan 1;12(2):141-150.
Ohneda, Osamu ; Ohneda, Kinuko ; Nomiyama, Hisayuki ; Zheng, Zhong ; Gold, Steven A. ; Arai, Fumio ; Miyamoto, Takeshi ; Taillon, Bruce E. ; McIndoe, Richard A. ; Shimkets, Richard A. ; Lewin, David A. ; Suda, Toshio ; Lasky, Laurence A. / WECHE : A novel hematopoietic regulatory factor. In: Immunity. 2000 ; Vol. 12, No. 2. pp. 141-150.
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