Wernicke-Korsakoff Syndrome in a Young Adult on Dialysis Who Showed Bilateral Ganglia Lesions

Masaoki Hidaka, Masaya Kumamoto, Tatsuya Suenaga, Ayaka Itsuji, Yuka Kanazawa, Seiji Goto, Hitonori Takaba, Takanari Kitazono

Research output: Contribution to journalArticlepeer-review


A 30-year-old man admitted with renal dysfunction (serum creatinine, 8.19 mg/dL) was diagnosed with immunoglobulin A nephritis through a renal biopsy. He was treated with intravenous methylprednisolone pulse therapy and urgent hemodialysis, and eventually, he underwent maintenance hemodialysis. On day 108, he developed amnesia. Magnetic resonance imaging revealed bilateral basal ganglia lesions. Wernicke encephalopathy (WE) was diagnosed based on decreased serum thiamine concentration (12.8 μg/dL; reference range, 24-66 μg/dL). Thiamine replacement therapy was initiated, but the Wernicke-Korsakoff syndrome persisted. Careful monitoring of thiamine is required in patients undergoing dialysis. In addition, patients with WE may exhibit bilateral basal ganglia lesions.

Original languageEnglish
Pages (from-to)113-118
Number of pages6
JournalInternal Medicine
Issue number1
Publication statusPublished - 2023
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Internal Medicine


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