TY - JOUR
T1 - Wernicke-Korsakoff Syndrome in a Young Adult on Dialysis Who Showed Bilateral Ganglia Lesions
AU - Hidaka, Masaoki
AU - Kumamoto, Masaya
AU - Suenaga, Tatsuya
AU - Itsuji, Ayaka
AU - Kanazawa, Yuka
AU - Goto, Seiji
AU - Takaba, Hitonori
AU - Kitazono, Takanari
N1 - Publisher Copyright:
2023 The Japanese Society of Internal Medicine.
PY - 2023
Y1 - 2023
N2 - A 30-year-old man admitted with renal dysfunction (serum creatinine, 8.19 mg/dL) was diagnosed with immunoglobulin A nephritis through a renal biopsy. He was treated with intravenous methylprednisolone pulse therapy and urgent hemodialysis, and eventually, he underwent maintenance hemodialysis. On day 108, he developed amnesia. Magnetic resonance imaging revealed bilateral basal ganglia lesions. Wernicke encephalopathy (WE) was diagnosed based on decreased serum thiamine concentration (12.8 μg/dL; reference range, 24-66 μg/dL). Thiamine replacement therapy was initiated, but the Wernicke-Korsakoff syndrome persisted. Careful monitoring of thiamine is required in patients undergoing dialysis. In addition, patients with WE may exhibit bilateral basal ganglia lesions.
AB - A 30-year-old man admitted with renal dysfunction (serum creatinine, 8.19 mg/dL) was diagnosed with immunoglobulin A nephritis through a renal biopsy. He was treated with intravenous methylprednisolone pulse therapy and urgent hemodialysis, and eventually, he underwent maintenance hemodialysis. On day 108, he developed amnesia. Magnetic resonance imaging revealed bilateral basal ganglia lesions. Wernicke encephalopathy (WE) was diagnosed based on decreased serum thiamine concentration (12.8 μg/dL; reference range, 24-66 μg/dL). Thiamine replacement therapy was initiated, but the Wernicke-Korsakoff syndrome persisted. Careful monitoring of thiamine is required in patients undergoing dialysis. In addition, patients with WE may exhibit bilateral basal ganglia lesions.
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U2 - 10.2169/internalmedicine.8910-21
DO - 10.2169/internalmedicine.8910-21
M3 - Article
C2 - 35598991
AN - SCOPUS:85145235524
SN - 0918-2918
VL - 62
SP - 113
EP - 118
JO - Internal Medicine
JF - Internal Medicine
IS - 1
ER -