TY - JOUR
T1 - Western versus Asian types of multiple sclerosis
T2 - Immunogenetically and clinically distinct disorders
AU - Kira, Jun Ichi
AU - Kanai, Takayuki
AU - Nishimura, Yasuharu
AU - Yamasaki, Kenji
AU - Matsushita, Sho
AU - Kawano, Yuji
AU - Hasuo, Kanehiro
AU - Tobimatsu, Shozo
AU - Kobayashi, Takuro
PY - 1996/10/1
Y1 - 1996/10/1
N2 - The polymorphism of HLA-DRB1, -DRB3, and -DRB5 genes as well as magnetic resonance images of the brain and spinal cord were studied in 57 Japanese patients with multiple sclerosis (MS). Twenty-three patients clinically displayed selective involvement of the optic nerve and spinal cord and were classified as having Asian-type MS. The other 34 patients had disseminated central nervous system involvement and were classified as having Western- type MS. Patients with Asian-type MS had fewer brain lesions shown by magnetic resonance imaging, but more gadolinium-enhanced spinal cord lesions than did patients with Western-type MS (47% vs 17%). Furthermore, the DR2- associated DRB1* 1501 allele and DRB5*0101 allele were associated with Western-type MS (41.2%), but not with either Asian-type MS (0%) or healthy control subjects (14.2%). Heterogeneity in the immunogenetic background and in the magnetic resonance imaging features between the two subtypes of MS thus suggests the presence of two etiologically distinct diseases in Asians.
AB - The polymorphism of HLA-DRB1, -DRB3, and -DRB5 genes as well as magnetic resonance images of the brain and spinal cord were studied in 57 Japanese patients with multiple sclerosis (MS). Twenty-three patients clinically displayed selective involvement of the optic nerve and spinal cord and were classified as having Asian-type MS. The other 34 patients had disseminated central nervous system involvement and were classified as having Western- type MS. Patients with Asian-type MS had fewer brain lesions shown by magnetic resonance imaging, but more gadolinium-enhanced spinal cord lesions than did patients with Western-type MS (47% vs 17%). Furthermore, the DR2- associated DRB1* 1501 allele and DRB5*0101 allele were associated with Western-type MS (41.2%), but not with either Asian-type MS (0%) or healthy control subjects (14.2%). Heterogeneity in the immunogenetic background and in the magnetic resonance imaging features between the two subtypes of MS thus suggests the presence of two etiologically distinct diseases in Asians.
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U2 - 10.1002/ana.410400405
DO - 10.1002/ana.410400405
M3 - Article
C2 - 8871575
AN - SCOPUS:0029910942
SN - 0364-5134
VL - 40
SP - 569
EP - 574
JO - Annals of Neurology
JF - Annals of Neurology
IS - 4
ER -