White-coat and masked hypertension are associated with albuminuria in a general population: The Hisayama Study

Jun Hata, Masayo Fukuhara, Satoko Sakata, Hisatomi Arima, Yoichiro Hirakawa, Koji Yonemoto, Naoko Mukai, Takanari Kitazono, Yutaka Kiyohara, Toshiharu Ninomiya

Research output: Contribution to journalArticle

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Abstract

Epidemiological and clinical studies have investigated the influence of hypertension on chronic kidney disease (CKD), but limited data are available for the associations of white-coat hypertension (WCHT), masked hypertension (MHT) and sustained hypertension (SHT) with kidney dysfunction in general populations. We examined the associations of these types of hypertension with CKD (albuminuria and reduction in estimated glomerular filtration rate (eGFR)) in a cross-sectional survey of 2974 community-dwelling Japanese aged ≥40 years. The types of hypertension were defined based on combined measurements of clinic and home blood pressures. Albuminuria was determined as urinary albumin-creatinine ratio (UACR) levels ≥30.0 mg g-1. The eGFR was calculated using the Japanese equation. The age- and sex-adjusted geometric mean of the UACR values was significantly higher in the subjects with WCHT (20.2 mg g-1), MHT (19.6 mg g-1) and SHT (31.6 mg g-1) than in those with normotension (NT) (12.5 mg g-1) (all P<0.001). Compared with NT, all types of hypertension were significantly associated with an increased likelihood of albuminuria (the age- and sex-adjusted prevalence of albuminuria; NT 14.1%, WCHT 26.3%, MHT 26.4% and SHT 43.3%; all P<0.001). These associations remained significant even after adjustment for other risk factors. However, the age- and sex-adjusted mean of eGFR and the prevalence of low eGFR (<60 ml min-1 per 1.73 m2) did not differ between NT and the three hypertension types. The associations of the types of hypertension with the likelihood of CKD were similar to those for albuminuria. Our findings suggest that WCHT, MHT and SHT are associated with albuminuria in the general Japanese population.

Original languageEnglish
Pages (from-to)937-943
Number of pages7
JournalHypertension Research
Volume40
Issue number11
DOIs
Publication statusPublished - Nov 1 2017

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Masked Hypertension
White Coat Hypertension
Albuminuria
Hypertension
Population
Glomerular Filtration Rate
Chronic Renal Insufficiency
Albumins
Creatinine
Independent Living
Epidemiologic Studies

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

White-coat and masked hypertension are associated with albuminuria in a general population : The Hisayama Study. / Hata, Jun; Fukuhara, Masayo; Sakata, Satoko; Arima, Hisatomi; Hirakawa, Yoichiro; Yonemoto, Koji; Mukai, Naoko; Kitazono, Takanari; Kiyohara, Yutaka; Ninomiya, Toshiharu.

In: Hypertension Research, Vol. 40, No. 11, 01.11.2017, p. 937-943.

Research output: Contribution to journalArticle

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abstract = "Epidemiological and clinical studies have investigated the influence of hypertension on chronic kidney disease (CKD), but limited data are available for the associations of white-coat hypertension (WCHT), masked hypertension (MHT) and sustained hypertension (SHT) with kidney dysfunction in general populations. We examined the associations of these types of hypertension with CKD (albuminuria and reduction in estimated glomerular filtration rate (eGFR)) in a cross-sectional survey of 2974 community-dwelling Japanese aged ≥40 years. The types of hypertension were defined based on combined measurements of clinic and home blood pressures. Albuminuria was determined as urinary albumin-creatinine ratio (UACR) levels ≥30.0 mg g-1. The eGFR was calculated using the Japanese equation. The age- and sex-adjusted geometric mean of the UACR values was significantly higher in the subjects with WCHT (20.2 mg g-1), MHT (19.6 mg g-1) and SHT (31.6 mg g-1) than in those with normotension (NT) (12.5 mg g-1) (all P<0.001). Compared with NT, all types of hypertension were significantly associated with an increased likelihood of albuminuria (the age- and sex-adjusted prevalence of albuminuria; NT 14.1{\%}, WCHT 26.3{\%}, MHT 26.4{\%} and SHT 43.3{\%}; all P<0.001). These associations remained significant even after adjustment for other risk factors. However, the age- and sex-adjusted mean of eGFR and the prevalence of low eGFR (<60 ml min-1 per 1.73 m2) did not differ between NT and the three hypertension types. The associations of the types of hypertension with the likelihood of CKD were similar to those for albuminuria. Our findings suggest that WCHT, MHT and SHT are associated with albuminuria in the general Japanese population.",
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