Whole genome sequences of 2 octogenarians with sustained cognitive abilities

Dorothee Nickles, Lohith Madireddy, Nihar Patel, Noriko Isobe, Bruce L. Miller, Sergio E. Baranzini, Joel H. Kramer, Jorge R. Oksenberg

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Although numerous genetic variants affecting aging and mortality have been identified, for example, apolipoprotein E ε4, the genetic component influencing cognitive aging has not been fully defined yet. A better knowledge of the genetics of aging will prove helpful in understanding the underlying biological processes. Here, we describe the whole genome sequences of 2 female octogenarians. We provide the repertoire of genomic variants that the 2 octogenarians have in common. We also describe the overlap with the previously reported genomes of 2 supercentenarians-individuals aged ≥110years. We assessed the genetic disease propensities of the octogenarians and non-aged control genomes and could not find support for the hypothesis that long-lived healthy individuals might exhibit greater genetic fitness than the general population. Furthermore, there is no evidence for an accumulation of previously described variants promoting longevity in the 2 octogenarians. These findings suggest that genetic fitness, as currently defined, is not the sole factor enabling an increased life span. We identified a number of healthy-cognitive-aging candidate genetic loci awaiting confirmation in larger studies.

Original languageEnglish
Pages (from-to)1435-1438
Number of pages4
JournalNeurobiology of Aging
Volume36
Issue number3
DOIs
Publication statusPublished - Mar 1 2015

Fingerprint

Genetic Fitness
Genome
Apolipoprotein E4
Biological Phenomena
Inborn Genetic Diseases
Genetic Loci
Causality
Mortality
Population
Cognitive Aging

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Ageing
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Nickles, D., Madireddy, L., Patel, N., Isobe, N., Miller, B. L., Baranzini, S. E., ... Oksenberg, J. R. (2015). Whole genome sequences of 2 octogenarians with sustained cognitive abilities. Neurobiology of Aging, 36(3), 1435-1438. https://doi.org/10.1016/j.neurobiolaging.2014.11.003

Whole genome sequences of 2 octogenarians with sustained cognitive abilities. / Nickles, Dorothee; Madireddy, Lohith; Patel, Nihar; Isobe, Noriko; Miller, Bruce L.; Baranzini, Sergio E.; Kramer, Joel H.; Oksenberg, Jorge R.

In: Neurobiology of Aging, Vol. 36, No. 3, 01.03.2015, p. 1435-1438.

Research output: Contribution to journalArticle

Nickles, D, Madireddy, L, Patel, N, Isobe, N, Miller, BL, Baranzini, SE, Kramer, JH & Oksenberg, JR 2015, 'Whole genome sequences of 2 octogenarians with sustained cognitive abilities', Neurobiology of Aging, vol. 36, no. 3, pp. 1435-1438. https://doi.org/10.1016/j.neurobiolaging.2014.11.003
Nickles, Dorothee ; Madireddy, Lohith ; Patel, Nihar ; Isobe, Noriko ; Miller, Bruce L. ; Baranzini, Sergio E. ; Kramer, Joel H. ; Oksenberg, Jorge R. / Whole genome sequences of 2 octogenarians with sustained cognitive abilities. In: Neurobiology of Aging. 2015 ; Vol. 36, No. 3. pp. 1435-1438.
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