ペリサイトは脳機能にとってなぜ重要なのか?

Translated title of the contribution: Why are pericytes important for brain functions?

Research output: Contribution to journalArticle

Abstract

Pericytes are mural cells embedded in the basal membrane surrounding endothelial cells in capillary and small vessels (from precapillary arterioles to postcapillary venules). They exist with a high coverage ratio to endothelial cells in the brain and play crucial roles in the formation and maintenance of the blood-brain barrier and the control of blood flow through a close interaction with endothelial cells. Thus, intactness of pericyte is absolutely needed for neuronal/ brain functions. Ageing, life-style diseases, hypoperfusion/ischemia, drugs, and genetic factors can primarily cause pericyte dysfunctions, thereby leading to the development or progression of various brain disorders, including cerebrovascular diseases. Because pericytes also play an important role in tissue repair after brain injuries, they have received much attention as a therapeutic target even from the standpoint of functional recovery.

Original languageJapanese
Pages (from-to)707-715
Number of pages9
JournalClinical Neurology
Volume59
Issue number11
DOIs
Publication statusPublished - Jan 1 2019

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Pericytes
Endothelial Cells
Brain
Cerebrovascular Disorders
Venules
Arterioles
Brain Diseases
Blood-Brain Barrier
Brain Injuries
Life Style
Ischemia
Maintenance
Membranes
Pharmaceutical Preparations
Therapeutics

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

ペリサイトは脳機能にとってなぜ重要なのか?. / Ago, Tetsuro.

In: Clinical Neurology, Vol. 59, No. 11, 01.01.2019, p. 707-715.

Research output: Contribution to journalArticle

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title = "ペリサイトは脳機能にとってなぜ重要なのか?",
abstract = "Pericytes are mural cells embedded in the basal membrane surrounding endothelial cells in capillary and small vessels (from precapillary arterioles to postcapillary venules). They exist with a high coverage ratio to endothelial cells in the brain and play crucial roles in the formation and maintenance of the blood-brain barrier and the control of blood flow through a close interaction with endothelial cells. Thus, intactness of pericyte is absolutely needed for neuronal/ brain functions. Ageing, life-style diseases, hypoperfusion/ischemia, drugs, and genetic factors can primarily cause pericyte dysfunctions, thereby leading to the development or progression of various brain disorders, including cerebrovascular diseases. Because pericytes also play an important role in tissue repair after brain injuries, they have received much attention as a therapeutic target even from the standpoint of functional recovery.",
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