Wider retinal artery trajectories in eyes with macular hole than in fellow eyes of patients with unilateral idiopathic macular hole

Naoya Yoshihara, Taiji Sakamoto, Takehiro Yamashita, Toshifumi Yamashita, Keita Yamakiri, Shozo Sonoda, Tatsuro Ishibashi

Research output: Contribution to journalArticle

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Abstract

Purpose: To determine whether the width of the retinal artery (RA) trajectory was associated with the presence of a macular hole (MH). Methods: A retrospective cross sectional case-control study was performed. The fundus photographs were rotated 90 degrees, and the coordinates of the best fit curve of the RA trajectory were determined automatically based on these plots using the ImageJ program. The converted coordinates were fit to a second degree polynomial (ax2/100 + bx + c) equation. The width and steepness of the RA trajectory, "a", of the eyes with a MH eye were compared to that of the fellow eyes. Results: One hundred and ten eyes of 55 consecutive patients (30 women) with a unilateral MH and healthy fellow eyes were analyzed. The mean age was 64.9 years (range 47-81 years). The constant 'a' was significantly smaller in eyes with a MH than that of the fellow eyes (0.379 ± 0.094 vs 0.416 ± 0.121, P = 0.001, paired t test), indicating that the RA trajectory was wider in the MH eyes than in the fellow eyes. There was a significant correlation between the axial length and 'a' of the RA trajectory in the MH eyes (R = 0.273, P = 0.044) and in the fellow eyes (R = 0.356, P = 0.008; Spearman's rank correlation coefficient). Conclusions: Because eyes with a MH have a significantly wider and flatter RA trajectory, there may be greater traction on the fovea which is located between the RA arches. The causative role of this finding is still unclear.

Original languageEnglish
Article numbere0122876
JournalPloS one
Volume10
Issue number4
DOIs
Publication statusPublished - Apr 13 2015

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Retinal Artery
Retinal Perforations
arteries
trajectories
eyes
Trajectories
Arches
traction (mechanics)
Polynomials
Traction
Nonparametric Statistics
case-control studies
photographs
Case-Control Studies

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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Wider retinal artery trajectories in eyes with macular hole than in fellow eyes of patients with unilateral idiopathic macular hole. / Yoshihara, Naoya; Sakamoto, Taiji; Yamashita, Takehiro; Yamashita, Toshifumi; Yamakiri, Keita; Sonoda, Shozo; Ishibashi, Tatsuro.

In: PloS one, Vol. 10, No. 4, e0122876, 13.04.2015.

Research output: Contribution to journalArticle

Yoshihara, Naoya ; Sakamoto, Taiji ; Yamashita, Takehiro ; Yamashita, Toshifumi ; Yamakiri, Keita ; Sonoda, Shozo ; Ishibashi, Tatsuro. / Wider retinal artery trajectories in eyes with macular hole than in fellow eyes of patients with unilateral idiopathic macular hole. In: PloS one. 2015 ; Vol. 10, No. 4.
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