Wnt signaling and glucocorticoid-induced osteoporosis

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Wnt signaling plays an important role not only in development and morphogenesis of embryos but in pathogenesis of various disorders including cancers. Analyses of the mutations in LDL receptor-related protein 5 (LRP5), a Wnt co-receptor, revealed that the Wnt signaling pathway is important for bone formation. Glucocorticoids suppress the canonical Wnt signaling pathway by such mechanisms as the enhancement the expression of dickkopf-1 (Dkk-1) and secreted frizzled-related protein 1 (sFRP1), and activation of the glycogen synthase kinase-3beta (GSK-3beta) activity. The inhibition of the canonical Wnt signal by glucocorticoid may be involved in the pathogenesis of glucocorticoid-induced osteoporosis.

Original languageEnglish
Pages (from-to)1812-1816
Number of pages5
JournalClinical calcium
Volume16
Issue number11
Publication statusPublished - Jan 1 2006

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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