Wnt Signaling in the Niche

Toshio Suda, Fumio Arai

Research output: Contribution to journalShort survey

36 Citations (Scopus)

Abstract

There is much interest in understanding the signals in the bone marrow niche that keep hematopoietic stem cells (HSCs) in a quiescent state. In the current issue of Cell Stem Cell, Fleming et al. (2008) report that blocking Wnt signaling in the niche increases the number of proliferating HSCs and reduces their ability to reconstitute the hematopoietic system of irradiated recipient mice. These findings show that Wnt/β-catenin activity is crucial for the maintenance of HSC quiescence in the bone marrow niche.

Original languageEnglish
Pages (from-to)729-730
Number of pages2
JournalCell
Volume132
Issue number5
DOIs
Publication statusPublished - Mar 7 2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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